摘要
Abstract
Objective To investigate the effects of different doses of remifentanil on hemodynamics and plasma cortisol of patients dur-ing general anesthesia induction period. Methods Totally 56 patients underwent general anesthesia surgery were selected and randomly divided into four groups, 14 cases in each group. All patients received the conventional treatment of midazolam, propofol and rocuronium, on this basis, Group A received fentanyl 2 μg/kg, Group B, Group C and Group D received remifentanil 0. 5, 1. 0, 1. 25 μg/kg, respectively. Results After treatment, the systolic blood pressure, diastolic blood pressure and heart rate in the four groups were decreased, the indexes in group C and group D were decreased more obviously than those in group A and group B ( P < 0. 05 ) , after tracheal intubation, the systolic blood pressure, diastolic blood pressure and heart rate in the four groups were increased, the indexes in group A and group B were increased more obviously ( P < 0. 05 ) . 4 min after tracheal intubation, cortisol in the four groups were increased, and group A and group B were increased more obviously, 6 min after tracheal intubation, cortisol in the four groups were decreased, and group C and group D were decreased more obviously ( P < 0. 05 ) . The incidence rates of hypotension and respiratory depression in group C and group D were significantly higher than those in group A and group B ( P < 0. 05 ) . Conclusion 0. 5-1. 0 μg/kg remifentanil used for patients during general anesthesia induction period has good central inhibition, it can reduce the damage caused by excessive drug inhibition.关键词
雷米芬太尼/血浆皮质醇/血流动力学/全身麻醉Key words
remifentanil/plasma cortisol/hemodynamics/general anesthesia分类
医药卫生
