摘要
Abstract
Objective To investigate the pathogenic factors, clinical manifestations and prognosis of drug induced liver disease ( DILD ) . Methods The clinical data of clinical symptoms, laboratory indexes, basic diseases, types of liver injury drugs and prognosis of 424 pa-tients with DILD was analyzed retrospectively, in order to analyze the pathogenic factors and clinical features. Results Hepatobiliary dis-eases, immune dysfunction, diabetes, hypertension, long-term drinking, over 45 years old were the risk factors of DILD. In 424 cases, there were 155 males ( 36. 56% ) and 269 females ( 63. 44% ) , the difference was statistically significant ( P < 0. 01 ) . Totally 257 cases ( 60. 61%) of DILD caused by traditional Chinese medicine, among the top 3, there were 17 cases ( 6. 61%) of Polygonum multiflorum, 11 cases ( 4. 28% ) of Tripterygium wilfordii, 8 cases ( 3. 11% ) of Sedum aizoon. Totally 167 cases ( 39. 39% ) of DILD caused by Western medicine, among the top 3, there were 72 cases ( 43. 11% ) of anti-tuberculosis drugs, 27 cases ( 16. 17% ) of psychotropic drugs, and 17 cases ( 10. 18%) of non steroidal anti-inflammatory drugs. There were no significant differences in the effects of Chinese medicine and Western medicine on liver injury ( P=0. 239 ) . After comprehensive treatment of internal medicine, the prognosis of DILD patients induced by traditional Chinese medicine or Western medicine was good, the difference was not statistically significant ( P=0. 889 ) . Conclusion The clinical manifestations of DILD are lack of specificity, mostly for occult diseases. DILI is not only associated with the treatment of drugs, but also with the patient′s own physique. For patients with disease risk factors, attention should be paid to the prevention of DILD. After comprehensive treatment, most DILD patients have good prognosis.关键词
药物性肝炎/临床表现/合理用药/多因素分析Key words
drug induced liver disease/clinical manifestations/rational drug use/multifactorial correlation analysis分类
医药卫生
