中国药业2017，Vol.26Issue(20)：13-17,5.DOI:10.3969/j.issn.1006-4931.2017.20.004
吲哚美辛亲水凝胶贴剂定量方法与前处理提取工艺正交优化
Optimization of Extraction Process of Quantitative Method and Pretreatment of Indomethacin Hydrophilic Gel Patch by Orthogonal Design
摘要
Abstract
Objective To optimize the extraction process and content determination method of Indomethacin Hydrophilic Gel Patch. Methods Quantitative analysis was performed by using HPLC - working curves,the extraction method,extracting solvent,time and pretreatment method were extracted by means of single factor and orthogonal design optimization. Results Finally,the extraction conditions of the patch were:after the patch paste was cut and broken,50 mL methanol was extracted for 90 min and extracted 1 time,or 25 mL methanol was extracted for 60 min and extracted 2 times. Conclusion Drug extraction process conditions in optimized patches is stable and reliable,which provides a good method for the quality evaluation of the patch.关键词
正交设计/提取工艺/吲哚美辛/含量测定/亲水凝胶/贴剂Key words
orthogonal design/extraction process/indometacin/content determination/hydrophilic gel/patch分类
化学化工引用本文复制引用
郭文韬,谢伟杰,张永萍,徐剑..吲哚美辛亲水凝胶贴剂定量方法与前处理提取工艺正交优化[J].中国药业,2017,26(20):13-17,5.基金项目
国家苗药工程技术研究中心项目[ 2014FU125Q09 ] （）
贵州省科技厅"百层次人才"培养计划项目[黔科合人才[ 2015 ] 4030号] （）
贵州省教育厅中药民族药(苗药)新剂型新制剂工程研究中心项目[黔教合KY字[ 2014 ] 22号] （苗药）
贵州省普通高等学校中药民族药制剂重点实验室[黔教合KY字[ 2016 ] 005 ]. （）
