摘要
Abstract
Objective To compare the effect and safety of preemptive analgesia with different doses of flurbiprofen axetil for postopera-tive analgesia in laparoscopic surgery. Methods A total of 400 patients underwent elective gynecological laparoscopic surgery in our hospital from May 2014 to May 2016 were selected and randomly divided into group A and group B,200 cases in each group. The group A was treated with flurbiprofen axetil of 0. 75 mg/kg during surgery,while the group B was treated with flurbiprofen axetil of 1. 0 mg/kg during surgery. The heart rate(HR) and mean arterial pressure (MAP) before surgery,during anesthesia,at the end of surgery and at 2 h after surgery,visual analogue scale(VAS)scores at 2,6,12 h after surgery and adverse reactions were compared between the two groups. Results The HR and MAP of group B were significantly lower than those of group A during anesthesia,at the end of surgery and at 2 h after surgery(P < 0. 05). The VAS scores of group B were significantly lower than those of group A at 2, 6,12 h after surgery(P < 0. 05). There was no significant difference in the total incidence rate of adverse reactions between the two groups (11. 50％ vs. 11. 00％,P > 0. 05). Conclusion Preemptive analgesia with flurbiprofen axetil (1. 0 mg/kg)is effective and safe for postoperative analgesia in laparoscopic surgery.关键词
氟比洛芬酯/超前镇痛/腹腔镜手术/镇痛效果/安全性Key words
flurbiprofen axetil/preemptive analgesia/laparoscopic surgery/analgesic effect/safety分类
医药卫生
