摘要
Abstract
Objective To observe the clinical effect of Shenqijianwei Granules combined with Shuganjieyu Capsules in the treatment of chronic atrophic gastritis (CAG) with anxiety-depression. Methods Totally 57 patients with CAG and anxiety-depression were randomly divided into the control group (n=28)and the combined group (n=29). The control group was treated with Vitacoenzyme Tablets and Paroxetine Hydrochloride Tablets orally,while the combined group was treated with Shenqijianwei Granules combined with Shuganjieyu Capsules. Four weeks was a course of treatment,and the two groups were treated with 3 courses. Results The scores of main clinical symptoms (epigastric pain,acid regurgitation,postprandial fullness,belching,early satiation) and gastric mucosa biopsy in the combined group were significantly lower than those in the control group (P < 0. 05). After treatment,the levels of serum biomarkers (sHLA-G,MG7-Ag,PGⅠ,IL-23 and TK1)in the two groups had significantly difference (P < 0. 05). The scores of anxiety and depression scale (HAD-A,HAD-D,HAMA and HAMD) in the combined group were significantly lower than those in the control group (P < 0. 05). The total effective rate of the combined group was significantly higher than that of the control group (96. 55％vs. 78. 57％,χ2=4. 275,P=0. 039 < 0. 05). The incidence rate of adverse reactions in the combined group was significantly lower than that in the control group during treatment(0 vs. 14. 29％,χ2=4. 456,P=0. 035 < 0. 05). Conclusion Shenqijianwei Granules combined with Shuganjieyu Capsules in the treatment of CAG with anxiety-depression can significantly improve the clinical efficacy,clinical symptoms and gastric mucosal lesion,regulate serum biomarker levels and improve anxiety and depression. It is safe and worthy of clinical promotion.关键词
参芪健胃颗粒/舒肝解郁胶囊/慢性萎缩性胃炎/焦虑抑郁/临床疗效Key words
Shenqijianwei Granules/Shuganjieyu Capsules/chronic atrophic gastritis/anxiety-depression/clinical effect分类
医药卫生
