中国医院用药评价与分析2017，Vol.17Issue(9)：1183-1185,3.DOI:10.14009/j.issn.1672-2124.2017.09.011
尤瑞克林用于急性脑梗死的抗炎效果及安全性
Anti-inflammatory Effects and Safety of Urinary Kallidinogenase in Treatment of Acute Cerebral Infarction
摘要
Abstract
OBJECTIVE:To observe the clinical efficacy of urinary kallidinogenase in treatment of acute cerebral infarction, and to probe into the anti-inflammatory effects and safety. METHDS: 108 patients with acute cerebral infarction admitted into the Second Affiliated Hospital of Mudanjiang Medical College were extracted to be divided into observation group and control group via the random number table, with 54 cases in each. Based on the conventional treatment, the control group was given Xuesaitong injections, while the observation group received urinary kallidinogenase injections, the treatment course last for 14 d. The national institutes of health stroke scale ( NIHSS) , hs-CRP level of two groups were compared before and after treatment. RESULTS: Before treatment, there was no statistically significant difference between two groups in the NIHSS score and hs-CRP level ( P > 0. 05 ) . After treatment, the NIHSS score and hs-CRP level decreased significantly compared with before treatment, and the observation group was lower than the control group, with statistically significant difference ( P <0. 05 ) . The total effective rate of observation group was 98. 14％(53/54), significantly higher than that of control group 77. 78％(42/54), with statistically significant difference(P<0. 05). There was no severe adverse drug reactions in both groups. CONCLUSIONS:The efficacy of urinary kallidinogenase in treatment of acute cerebral infarction is remarkable, which can significantly reduce the serum hs-CRP level and relieve inflammation of patients with few adverse drug reactions.关键词
尤瑞克林/急性脑梗死/超敏C反应蛋白/注射用血塞通Key words
Urinary Kallidinogenase/Acute cerebral infarction/hs-CRP/Xuesaitong injections分类
医药卫生引用本文复制引用
王彬,张凤云,耿峰,杨淑芹,张本卓..尤瑞克林用于急性脑梗死的抗炎效果及安全性[J].中国医院用药评价与分析,2017,17(9):1183-1185,3.基金项目
牡丹江医学院科学技术研究项目(No. ZS201522) （No. ZS201522）
