中国医院用药评价与分析2017，Vol.17Issue(9)：1193-1195,3.DOI:10.14009/j.issn.1672-2124.2017.09.015
不同剂量阿托伐他汀对冠心病合并微量蛋白尿患者血脂及尿微量白蛋白水平的影响
Effect of Different Dosages of Atorvastatin on Serum Lipid and Urine Microalbumin in Patients with Coronary Heart Disease Complicated With Microalbuminuria
薛娟 1刘书培 1梁瑾 1高磊2
作者信息
- 1. 河南科技大学第一附属医院检验科,河南洛阳 471003
- 2. 河南科技大学第一附属医院消化内科,河南洛阳 471003
- 折叠
摘要
Abstract
OBJECTIVE:To probe into the effect of different dosages of atorvastatin on serum lipid and urine microalbumin in patients with coronary heart disease ( CHD ) complicated with microalbuminuria. METHODS: 82 patients with CHD complicated with microalbuminuria admitted into the First Affiliated Hospital of Henan University of Science and Technology from Apr. 2015 to Oct. 2016 were selected and divided into observation group and control group according to the admission sequences ( odd numbers were set as observation group, even numbers were set as control group) , with 41 cases in each group. Both groups were given conventional therapy, in addition, the control group was treated with atorvastatin for 10 mg/d, while the observation group was given atorvastatin for 20 mg/d. The clinical efficacy and incidence of adverse drug reactions of both groups were observed, levels of serum lipid and mALB of two groups before and after treatment were compared. RESULTS: The total effective rate of observation group was 95. 12％ (39/41), which was significantly higher than that of the control group [80. 49％(33/41)], with statistically significant difference ( P <0. 05 ) . After treatment, levels of TC, TG, LDL-C and mALB of both groups were significantly lower than those of before treatment, and those of observation group were significantly lower than the control group; level of HLD-C of both groups were significantly higher than that of before treatment, and that of observation group was significantly higher than the control group, with statistically significant differences (P<0. 05). There was no significant difference in the incidence of adverse reactions between two groups ( P > 0 . 05 ) . CONCLUSIONS:Atrovastatin can effectively improve the levels of serum lipid of patients with CHD complicated with microalbuminuria, and reduce the urine microalbumin. Besides, the efficacy of dosage of 20 mg/d is better than that of 10 mg/d.关键词
冠心病/微量蛋白尿/血脂/阿托伐他汀Key words
Coronary heart disease/Microalbuminuria/Serum lipid/Atorvastatin分类
医药卫生引用本文复制引用
薛娟,刘书培,梁瑾,高磊..不同剂量阿托伐他汀对冠心病合并微量蛋白尿患者血脂及尿微量白蛋白水平的影响[J].中国医院用药评价与分析,2017,17(9):1193-1195,3.
