中国肿瘤生物治疗杂志2017，Vol.24Issue(9)：990-994,5.DOI:10.3872/j.issn.1007-385x.2017.09.011
托珠单抗治疗CAR-T细胞治疗难治复发多发性骨髓瘤后细胞因子释放综合征的疗效
Effects of tocilizumab regimen on cytokine release syndrome for patients with relapsed or refractory multiple myeloma treated by CAR-T cell immunotherapy
摘要
Abstract
Objective:To observe the therapeutic effect oftocilizumab on cytokine release syndrome (CRS) for patients with relapsed or refractory multiple myeloma (MM) treated by CAR-T cell immunotherapy.Methods:From February 2016 to February 2017,24 patients with relapsed or refractory multiple myeloma treated by CAR-T cell immunotherapy in the Department of Hematology of Second Affiliated Hospital of Medical College,Xi'an Jiaotong University were included as study subjects.Tocilizumab (4-8 mg/kg·d) was applied on MM patients with grade 2 or above,and the treatment efficacy,side effects,and the changes of hypersensitive C-reactive protein (HsCRP) etc were observed.Results:Twenty-one of the 24 patients suffered from CRS during the CAR-T treatment.According to the CRS classification criteria,7 patients had grade 1 CRS reaction,7 patients with grade 2,5 patients with grade 3,and 2 patients with grade 4.The manifestations of CRS were hyperpyrexia,significant increase in cytokines and HsCRP level with the most obvious increase in IL-6.Fourteen CRS patients with grade 2 or above were treated by tocilizumab and their clinical symptoms were obviously alleviated:the temperature was rapidly decreased and cyto kines and hypersensitive C-reactive protein dropped to normal gradually.In the process of treatment,no obvious side effects were observed.Conclusion:Tocilizumab showed a significant clinical efficacy in the treatment of CRS,which greatly guaranteed the safety of the MM patients in the CAR-T treatment.关键词
托珠单抗/嵌合抗原受体修饰T细胞/多发性骨髓瘤/细胞因子释放综合征Key words
tocilizumab/chimeric antigen receptor T cell/multiple myeloma/cytokine release syndrome分类
医药卫生引用本文复制引用
张亦琳,杨云,古流芳,范晓虎,赵万红,张王刚,刘捷,陈银霞,曹星梅,何爱丽,王剑利,杨楠..托珠单抗治疗CAR-T细胞治疗难治复发多发性骨髓瘤后细胞因子释放综合征的疗效[J].中国肿瘤生物治疗杂志,2017,24(9):990-994,5.基金项目
西安交通大学第二附属医院重大医疗技术资助项目(No.XJS201601). Project supported by the Major Medical and Technical Programs of Second Affiliated Hospital of Medical College,Xi'an Jiaotong University(No.XJS201601) （No.XJS201601）
