中国肿瘤生物治疗杂志2017，Vol.24Issue(9)：1002-1005,4.DOI:10.3872/j.issn.1007-385x.2017.09.013
lncRNA MALAT1在弥漫性大B细胞淋巴瘤患者中的表达及其临床意义
Expression and clinical significance of lncRNA MALAT1 in diffuse large B cell lymphoma
摘要
Abstract
Objective:To investigate the expression of lncRNA MALAT1 (long non-coding RNAs,metastasis-associated lung adenocarcinoma transcript 1) in the serum of DLBCL (diffuse large B-cell lyrnphoma) patients,and to analyze its correlation to clinical prognosis.Methods:The blood samples of 82 DLBCL patients and 32 RLH patients (lymph node reactive hyperplasia),who were diagnosed at Hematology Department of People's Hospital of Sichuan Province from January 2010 to December 2015 with complete clinical data,were collected for this study.lncRNA MALAT1 expression was detected by Real-time fluorescence quantitative PCR,and the relationship between lncRNA MALAT1 expression with clinical pathological features and prognosis were analyzed.Results:Compare with RLH patients,lncRNA MALAT1 expression was significantly increased in DLBCL patients (7.48 ±0.27 vs 1.28±0.45,P＜0.01).In addition,lncRNA MALAT1 was significantly correlated with tumor size,clinical stage,B symptoms and international prognostic index (IPI) scores.The median progression free survival time (PFS) of patients with high lncRNA MALAT1 expression was significantly shorter than those with low expression ([16.43± 2.05] months vs [32.01±3.20] months,P＜0.01).Cox multivariate analyses verified that lncRNA MALAT1 and IPI scores were independent predictive factors for DLBCL prognosis.Conclusion:The high expression of lncRNA MALAT1 in DLBCL patients was correlated with multiple clinicopathological parameters.,and it is expected to become a new tumor marker for DLBCL prognosis.关键词
弥漫性大B细胞淋巴瘤/lncRNA MALAT1/临床病理特征/预后Key words
diffuse large B cell lymphoma/lncRNA MALA1/clinicopathologic feature/prognosis分类
医药卫生引用本文复制引用
黄珊,赵凤,刘迪,谢可..lncRNA MALAT1在弥漫性大B细胞淋巴瘤患者中的表达及其临床意义[J].中国肿瘤生物治疗杂志,2017,24(9):1002-1005,4.基金项目
四川省卫生和计划生育委员会科技资助项目(No.16PJ475).Project supported by the Health and Family Planning Commission of Sichuan Province(No.16PJ475) （No.16PJ475）
