摘要
Abstract
Objective To study the feasibility of insulin like factor 3 (INSL-3) in evaluation of adolescent juvenile varicocele. Methods Eighty cases of ado-lescent varicocele patients were admitted to positive group, while 80 healthy young volunteers were admit-ted to normal control group. The left testicular volume, testicular atrophy index (AI), serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), semen volume, sperm density, sperm motility (a+b), normal sperm morphology and INSL-3 were compared between two groups. The difference of INSL-3 expression between two groups was statistically analyzed. The correlation between INSL-3 and other indexes was analyzed. Results Compared with the control group, patients in positive group had smaller left testicular volume and tes-ticular atrophy index. For positive group, serum follicle stimulating hormone (6.21 ± 2.41) IU/L, luteinizing hor-mone (6.02±1.47) IU/L and testosterone (7.87±1.66) μg/L increased significantly, but semen volume (2.86±1.19) mL, sperm density (60.77 ± 35.97) M/mL, sperm motility (a+b) (29.14 ± 16.77) % and the normal form of sperm (60.31 ± 18.66) % were significantly decreased (P<0.05). INSL-3 levels (259.6 ± 30.7) pg/mL were significantly decreased (P<0.01). The concentration of INSL-3 correlated with sperm motility (a+b) and normal morphologi-cal sperm rate. Conclusion Serum INSL-3 levels are closely related to juvenile varicocele, and can be used for the diagnosis and intervention of juvenile varicocele.关键词
青少年/精索静脉曲张/胰岛素样因子3/激素/诊断Key words
Adolescence/varicocele/insulin like factor 3/hormone/diagnosis分类
医药卫生
