中华临床免疫和变态反应杂志2017，Vol.11Issue(3)：232-240,9.DOI:10.3969∕j.issn.1673-8705.2017.03.007
1883例住院药疹患者致敏药物分析
Analysis on Causative Drugs of 1883 Drug Eruptions in a Hospitalized Population
杨凡萍 1陈圣安 1朱沁媛 1吴晓瑾 1熊浩 1陈姿桦 1郜旭东 1骆肖群1
作者信息
- 1. 复旦大学附属华山医院皮肤科, 上海200040
- 折叠
摘要
Abstract
Objective To analyze the causative drugs of drug eruptions, basing on the data of a hos-pitalized population from Department of Dermatology, Huashan Hospital during past 10 years. Methods Clinical records of patients with diagnosis of drug eruption were collected and analyze retrospectively, who were admitted into inpatients ward of Department of Dermatology, Huashan Hospital since January 2007 to December 2016. Results A total of 1883 [ male: 652, ( 34. 63%) , female 1231 ( 65. 37%) ] pa-tients were enroll in this study. The most common types of drug eruptions were urticaria (27. 19%), mac-ulopapular exanthema (MPE, 24. 69%), erythema multiforme (EM) -like eruptions (22. 04%), fol-lowed by three kinds of severe types including Stevens-Johnson syndrome ( SJS, 12. 16%) , drug reaction with eosinophils and systemic syndrome ( DRESS, 4. 30%) and toxic epidermal necrolysis ( TEN, 4. 25%) . 53. 43% patients were diagnosed as multiple drugs induced drug eruptions and 45. 83% as single drug induced drug eruptions. The top five most common causative drugs for single drug induced drug eruptions were antibiotics ( 28. 85%) , Traditional Chinese medicine ( TCM, 15. 99%) , antiepileptic agents (13. 56%), anti-hyperuricemia agents (12. 86%) and antipyretic/analgesic agents (9. 15%). The top five most common causative drugs for single drug induced severe drug eruptions were antiepileptic agents ( 36. 15%) , anti-hyperuricemia agents ( 31. 46%) , antibiotics ( 7. 98%) , TCM ( 5. 63%) and antipyretic/analgesic agents ( 5. 63%) . There was one kind of antibiotics and at least two kinds of antibi-otics in suspected causative drugs in 36. 18% and 31. 41% patients with multiple drugs induced drug eruptions respectively. 37. 97% patients with multiple drugs induced drug eruptions were prescribed at least one kind of TCM within the latency period. Conclusion The top two kinds of most common causa-tive drugs for drug eruptions were antibiotics and TCM. The number of TCM induced drug eruptions in-creased remarkably during the recent years. TCM induced drug eruptions should be vigilant.关键词
药疹/抗生素/中药/致敏药物Key words
drug eruptions/anti-bacterial agents/medicine/Chinese traditional/causative drugs分类
医药卫生引用本文复制引用
杨凡萍,陈圣安,朱沁媛,吴晓瑾,熊浩,陈姿桦,郜旭东,骆肖群..1883例住院药疹患者致敏药物分析[J].中华临床免疫和变态反应杂志,2017,11(3):232-240,9.
