中华临床免疫和变态反应杂志2017，Vol.11Issue(3)：264-268,5.DOI:10.3969∕j.issn.1673-8705.2017.03.012
系统性红斑狼疮并发蛋白丢失性肠病的危险因素
Risk Factors of Patients with Protein-losing Enteropathy in Systemic Lupus Erythematosus
摘要
Abstract
Objective To analyze clinical characteristics, laboratory findings, and risk factors of the protein-losing enteropathy ( PLE) in systemic lupus erythematosus ( SLE). Methods A retrospective, case-control study was performed in 60 patients with SLE-related PLE ( PLE group) and 120 patients with active SLE ( control group) admitted to our center from January 2000 to December 2015. Variables with sig-nificant P values between groups in the univariate analysis were further analyzed by a multivariate Logistic regression model to predict independent risk factors for SLE-related PLE. Results The PLE group had lower mean serum albumin and 24-hour urine protein levels, higher mean total plasma cholesterol levels, and greater frequencies of anti-SSA and SSB positivity compared with the control group. Anti-SSA seropositivity, hypoalbuminemia, and hypercholesterolemia were independent risk factors for SLE-related PLE. Conclusion SLE-related PLE should be considered when an SLE patient presents with anti-SSA antibody seropositivity, hypercholesterolemia, and severe hypoalbuminemia.关键词
红斑狼疮,系统性/蛋白丢失性肠病/自身抗体Key words
lupus erythematosus,systemic/protein-losing enteropathies/autoantibodies分类
医药卫生引用本文复制引用
陈真,苏丽,李梦涛,王婷,王迁,田新平,曾小峰..系统性红斑狼疮并发蛋白丢失性肠病的危险因素[J].中华临床免疫和变态反应杂志,2017,11(3):264-268,5.基金项目
福建省自然科学基金 (2015J01384), 福建省卫生系统中青年骨干人才培养项目 (2015-ZQN-JC-27) （2015J01384）
