广东医学2017，Vol.38Issue(18)：2782-2785,2789,5.
非肥胖型多囊卵巢综合征胰岛素抵抗与糖、脂代谢及脂肪分布的关系
The impact of insulin resistance on clinical,hormonal and metabolic parameters and fat distribution in non -obese women with polycystic ovary syndrome
摘要
Abstract
Objective To assess the effects of insulin resistance (IR)on glucose and lipid metabolism and fat distribution in non - obese women with polycystic ovary syndrome (PCOS). Methods Sixty non - obese (body mass in-dex < 28 kg/ m2 )PCOS subjects were included,among whom 40 were in IR group and 20 in non - insulin resistant group. Clinical hormonal,metabolic characteristics and fat distribution of the two groups were compared. Results The insulin resistant group and non - insulin resistant group had similar age,weight,BMI,waistline,hipline,waist - to - hip ratio,triglyceride,total cholesterol,low - density lipoprotein cholesterol,and high - density lipoprotein cholesterol (P >0. 05). Compared to non - insulin resistant group,the insulin resistant group had significantly higher systolic blood pres-sure (SBP),diastolic blood pressure (DBP),fasting plasma glucose (FPG),fasting insulin (FINS),and free androgen index (FAI);and significantly lower sex hormone binding globulin (SHBG)(P < 0. 05). The insulin resistant group and non - insulin resistant group had similar total fat mass,total fat percentage,and lean mass (P > 0. 05). The insulin re-sistant group had significantly higher trunk fat percentage,android fat percentage,trunk fat/ lower limb fat,android fat/gynoid fat than non - insulin resistant group (P < 0. 05). HOMA - IR values were found to be positively correlated with trunk fat/ lower limb fat (r = 0. 430,P < 0. 01),android fat/ gynoid fat (r = 0. 399,P < 0. 05),and lean mass (r =0. 366,P < 0. 05). In a multiple regression analysis,both trunk fat/ lower limb fat and lean mass were independent pre-dictors of IR. Conclusion Central fat distribution plays an important role in the occurrence of IR in Nob - PCOS sub-jects. It is important not only to pay attention to the treatment of IR,but also to reduce their visceral fat.关键词
多囊卵巢综合征/胰岛素抵抗/脂肪分布Key words
polycystic ovary syndrome/insulin resistance/fat distribution引用本文复制引用
刘欣,张莹,陈琳,闫嘉贺,郑思远,龚懿,麦婷婷..非肥胖型多囊卵巢综合征胰岛素抵抗与糖、脂代谢及脂肪分布的关系[J].广东医学,2017,38(18):2782-2785,2789,5.基金项目
国家自然科学基金资助项目(编号:81200607),广东省产科重大疾病重点实验室自主课题(编号:2012Z05) （编号:81200607）
