国际医药卫生导报2017，Vol.23Issue(20)：3175-3178,4.DOI:10.3760/cma.j.issn.1007-1245.2017.20.012
宫颈癌Foxm1蛋白表达与临床意义
Foxm1 protein expression in cervical cancer and its clinical significance
摘要
Abstract
Objective To explore the role of Foxm1 in the occurrence and progression of cervical cancer and its significance in the early detection and severity evaluation of cervical cancer.Methods 43 specimens of cervical cancer tissue and 35 specimens of normal cervical tissue were collected.The Foxm1 protein expression situation in these sample was detected by immunohistochemical method,the relationship between the overall Foxml protein expression level,the nucleus Foxm1 protein expression level in cervical cancer tissue and pathological features were analyzed.Results The positive expression rate of Foxml protein in cervical cancer tissue was significantly higher than that in normal cervical tissue (P＜0.001).The Foxml protein expression score in cervical cancer tissue was significantly higher than that in normal cervical tissue (P＜0.001).The total Foxm1 protein expression scores among different pathological types,differentiated degree,FIGO stages,lymph node metastasis were not statistically significant (P＞0.05).The tumor cell nucleus Foxm1 protein expression level in patients with low differentiation,Ⅱ stage,lymph node metastasis were significantly higher than those in patients with high or moderate differentiation,0-Ⅰ stage,and patients without lymph node metastasis (P＜0.001).Conclusion Foxm1 protein may be associated with the occurrence and progress of cervical cancer,detection of the nucleus Foxm1 protein positive expression level may be conducive to early finding cervical malignant lesions and evaluating severity of cervical cancer.关键词
宫颈癌/Foxm1蛋白/细胞核Key words
Cervical cancer/Foxm1 protein/Nucleus引用本文复制引用
郭春凤..宫颈癌Foxm1蛋白表达与临床意义[J].国际医药卫生导报,2017,23(20):3175-3178,4.
