摘要
Abstract
Objective To investigate the effect of magnesium sulfate combined with low molecular weight heparin on blood pressure control and maternal and neonatal outcomes in severe preeclampsia patients.Methods From January 2014 to September 2016,86 patients with severe preeclampsia in our hospital were divided into control group and observation group according to the treatment plan,43 cases in each group.The control group was treated with magnesium sulfate,and the observation group was treated with low molecular weight heparin on the basis.Blood pressure [diastolic blood pressure (DBP),systolic blood pressure (SBP)],coagulation function index [blood viscosity,blood flow resistance index (RI),hematocrit (HCT)] of the two groups before and after treatment were compared,and adverse pregnancy outcomes were statistically analyzed as well.Results There were no statistically significant differences in SBP,DBP,blood viscosity,RI,and HCT levels between the two groups before treatment (P＞0.05);after treatment,the levels of SBP [(138.25±8.43) mmHg],DBP [(92.25±5.17) mmHg],blood viscosity [(1.43±0.27) mPa·s],RI [(0.31±0.06)],and HCT [(39.58±5.33)％] of the observation group were all lower than those of the control group,with statistically significant differences (P＜0.05).The rate of premature delivery in the observation group was 9.30％ (4/43),the rate of postpartum hemorrhage was 4.65％ (2/43),the rate of fetal distress was 6.98％ (3/43),and the rate of neonatal asphyxia was 2.33％ (1/43),which were all lower than those in the control group [25.58％ (11/43),18.60％ (8/43),23.26％ (10/43),18.60％ (8/43)],with statistically significant differences (P＜0.05).Conclusion In the treatment of severe preeclampsia,magnesium sulfate combined with low molecular weight heparin can effectively reduce blood pressure level,improve blood hypercoagulable state,and thus it can help improve maternal and neonatal outcomes.关键词
重度子痫前期/硫酸镁/低分子肝素/血压/母婴结局Key words
Severe preeclampsia/Magnesium sulfate/Low molecular weight heparin/Blood pressure/Maternal and neonatal outcomes
