广东药科大学学报2017，Vol.33Issue(5)：600-605,6.DOI:10.16809/j.cnki.2096-3653.2017072701
灯盏花-大黄配伍的提取工艺优化研究
Optimization and scaled-up production of extraction process in compatibility of Erigeron breviscapus with Rheum
摘要
Abstract
Objective To optimize the extraction process and scaled-up production of compatibility of Erigeron breviscapus with Rheum and provide support for the preparation of Erigeron breviscapus-Rheum capsule. Methods The single-factor experiments coupled with orthogonal test were used to evaluate the effects of ethanol concentration, reflux time and extraction times on the contents of breviscapine, emodin and chrysophanol. The optimal extraction process was applied for scaled-up production. Results The optimal process conditions were as follows, extracted with 60% ethanol for 30 min of refluxing time, and only once extraction. And the ethanol concentration had significant influence on the extraction of Erigeron breviscapus-Rheum. The content of the extract was stable in the 3 batches of scaled-up production samples, which had no significant difference between lab batch and scaled-up samples. Conclusions The optimized extraction process was stable and practical, which was suitable for the scaled-up production, and it provided a foundation for the preparation of Erigeron breviscapus-Rheum capsule.关键词
灯盏花/大黄/提取工艺/生产放大Key words
Erigeron breviscapus/Rheum/extraction process/scaled-up production分类
医药卫生引用本文复制引用
赵紫玉,张雪娟,陈昕,黄莹,黄郑炜,崔影彤,潘昕,吴传斌..灯盏花-大黄配伍的提取工艺优化研究[J].广东药科大学学报,2017,33(5):600-605,6.基金项目
国家自然科学基金青年项目(81703431) （81703431）
药物制剂产业技术创新公共支撑平台(201509030006) （201509030006）
高校基本科研业务费中山大学青年教师培育项目( 16ykpy23) （ 16ykpy23）
广州市科技计划项目广州市珠江新星专项( 1317000297) （ 1317000297）
