广东药科大学学报2017，Vol.33Issue(5)：667-670,4.DOI:10.16809/j.cnki.2096-3653.2017052502
深圳孕妇携带B族链球菌的血清型和毒素基因分析
Analysis of serotypes and virulence genes of group B Streptococcus carried by pregnant women in Shenzhen
摘要
Abstract
Objective To investigate the carriage rate, and analyze the serotypes and virulence genes of group B Streptococcus( GBS) among pregnant women in Shenzhen. Methods Face-to-face questionnaire and vaginal swabs were collected from 1277 study participants. PCR was used to test the serotypes and virulence genes. The Fisher' s exact test was used to analyze the relation between serotypes and virulence genes. Results The carriage rate of GBS among pregnant women was 4.5%. The predominant serotypes of GBS isolates were Ⅲ( 56.1%) ,Ⅰa( 21.0%) and Ⅴ( 12.3%) , and the predominant virulence genes were Rib( 49.1%) , Epsilon( 28.1%) and AlphaC( 21.1%) . There was a relation between serotypes and virulence genes. SerotypeⅢisolates were more likely to carry the Rib gene, serotypeⅠa isolates were more likely to carry the Epsilon gene, and serotype V isolates were more likely to carry the AlphaC gene. Conclusion There is a relation between serotypes and virulence genes, suggesting that the potential pathogenic ability of different strains may be different.关键词
B族链球菌/血清型/毒素基因Key words
group B streptococcus/serotypes/virulence gene分类
医药卫生引用本文复制引用
陈智尧,曹雪莲,温国明,颜春荣,吴传安,李顺铭,叶小华..深圳孕妇携带B族链球菌的血清型和毒素基因分析[J].广东药科大学学报,2017,33(5):667-670,4.基金项目
广东省科技计划项目( 2014A020212306) （ 2014A020212306）
深圳龙华新区科技创新资金( 20151229A1030122) （ 20151229A1030122）
