临床与病理杂志2017，Vol.37Issue(9)：1816-1820,5.DOI:10.3978/j.issn.2095-6959.2017.09.008
铁调素在非小细胞肺癌组织和血清中的表达及其与临床病理特征的相关性
Expression of hepcidin in tumor tissues and serum and its correlation with clinicopathological features of non-small cell lung cancer
摘要
Abstract
Objective: To investigate the expression levels of hepcidin in tumor tissues and serum of non-small cell lung cancer, and study its relationship with the clinicopathological features. Methods: Immunohistochemistry was applied to detect hepcidin protein in 60 non-small cell lung cancer patients. 吀e levels of hepcidin in serum were detected by ELISA. Results: Both of hepcidin positive rates in tissues and hepcidin levels in serum were related to clinical stages and distant metastasis, but not with sex, gender, tumor differentiation degree, pathological pattern and lymphatic metastasis. There is no relationship between the levels of hepcidin in tumor tissues and serum.Conclusion: Hepcidin positive rates in tissues and levels in serum were related to clinical stages and distant metastasis in NSCLC patients. Further study is needed to explore the mechanism.关键词
非小细胞肺癌/铁调素/免疫组织化学/远处转移Key words
non-small cell lung cancer/hepcidin/immunohistochemistry/metastasis引用本文复制引用
毛旭华,汤俊明,乔国洪,陈姝颖,井昶雯..铁调素在非小细胞肺癌组织和血清中的表达及其与临床病理特征的相关性[J].临床与病理杂志,2017,37(9):1816-1820,5.基金项目
江苏省卫生和计划生育委员会科研项目(Z201602) （Z201602）
无锡市卫生和计划生育委员会面上项目(MS201536).This work was supported by the Scientific Research Project of Health and Family Planning Commission of Jiangsu Province(Z201602) and the Project of Health and Family Planning Commission of Wuxi City(MS201536), China. （MS201536）
