临床与病理杂志2017，Vol.37Issue(9)：1821-1824,4.DOI:10.3978/j.issn.2095-6959.2017.09.009
CDX2和Villin在胃黏膜病变中的表达及其临床病理意义
Expression of CDX2 and Villin in gastric mucosal lesions and their clinical pathologic significance
王见璋 1李炜霞 1何志明 1黄金凤1
作者信息
- 1. 广州中医药大学顺德医院病理科,广东 佛山 528333
- 折叠
摘要
Abstract
Objective: To investigate the expression of CDX2 and Villin in gastric mucosal lesions and their clinicopathological significance and diagnostic role. Methods: Ninety cases of gastric mucosa biopsy specimens in total, including 21 cases of chronic gastritis, 22 cases of chronic stomach disease associated with intestinal metaplasia, 25 cases of gastric intraepithelial neoplasia, and gastric carcinoma 22 cases, were collected from our hospital from January 2015 to May 2017. The immunohistochemical methods were used to detect the expression of CDX2 and Villin in the gastric mucosal biopsy tissue. Results: CDX2 and Villin had high expression in patients with intestinal metaplasia,gastric intraepithelial neoplasia and gastric cancer, and their positive rate was significantly higher than that of chronic gastritis, the differences were statistically significant (P<0.01). CDX2 was positively correlated with Villin (P<0.01).Conclusion: Both CDX2 and Villin are expressed in the intestinal metaplasia, gastric intraepithelial neoplasia and gastric cancer tissue, suggesting that the two may play an important role in the occurrence of gastric cancer (especially gastrointestinal carcinoma), at the same time, it can be used as the basis for the auxiliary diagnosis of gastric cancer and precancerous lesions (especially morphology is difficult to determine).关键词
胃癌/肠上皮化生/胃上皮内瘤变/CDX2/VillinKey words
gastric carcinoma/intestinal metaplasia/gastric intraepithelial neoplasia/CDX2/Villin引用本文复制引用
王见璋,李炜霞,何志明,黄金凤..CDX2和Villin在胃黏膜病变中的表达及其临床病理意义[J].临床与病理杂志,2017,37(9):1821-1824,4.
