临床与病理杂志2017，Vol.37Issue(9)：1825-1832,8.DOI:10.3978/j.issn.2095-6959.2017.09.010
长链非编码RNA WIF1-1在食管鳞状细胞癌组织中的表达及其临床意义
Expression and clinical significance of long noncoding RNA WIF1-1 in esophageal squamous cell carcinoma
许海蓉 1黄磊 2姚国亮 3司新敏1
作者信息
- 1. 南京医科大学第一附属医院消化内科,南京 210029
- 2. 南京医科大学附属南京市儿童医院普外科,南京 210008
- 3. 苏州大学第三附属医院心胸外科,江苏 常州 213003
- 折叠
摘要
Abstract
Objective: To investigate the expression level of long noncoding RNA (lncRNA) WIF1-1 and its related prognostic value in esophageal squamous cell carcinoma (ESCC). Methods: The expressions of lncRNA WIF1-1 in 50 ESCC tissues and the corresponding normal tissues were detected via RT-qPCR method. The association between long non-coding RNA WIF1-1 expression and clinical characteristics was evaluated via Chi-square test. Results: The expression of WIF1-1 in ESCC tissues decreased significantly compared with that in the corresponding normal tissues, the difference was statistically significant (P<0.5). Furthermore, WIF1-1 was negatively related to the lymph nodes metastasis, TNM and clinical stage. Overall survival (OS) and progressionfree survival (PFS) were significantly shorter in ESCC patients with lower expression level of lncRNA WIF1-1. Moreover, the down-regulated WIF1-1 expression was significantly correlated with the shorter survival of ESCC patients. The results of univariate and multivariate analysis revealed the WIF1-1 expression acted as an independent prognostic factor both in OS and PFS. Conclusion: The lncRNA WIF1-1 can be an important and potential suppressor of ESCC, and the expression of WIF1-1 may serve as another promising therapeutic target and prognostic biomarker in future clinic.关键词
WIF1-1/长链非编码RNA/食管鳞癌/预后Key words
WIF1-1/long non-coding RNA/esophageal squamous cell carcinoma/prognosis引用本文复制引用
许海蓉,黄磊,姚国亮,司新敏..长链非编码RNA WIF1-1在食管鳞状细胞癌组织中的表达及其临床意义[J].临床与病理杂志,2017,37(9):1825-1832,8.
