临床与病理杂志2017，Vol.37Issue(9)：1950-1953,4.DOI:10.3978/j.issn.2095-6959.2017.09.031
组织蛋白酶参与皮肤生理的研究进展
Advances of cathepsin in skin physiology
摘要
Abstract
Cathepsins (Cat) are the main members of the cysteine protease family, and relate closely to some dermatosis, for example, cutaneous tumor, chronic inflammation. Many recent investigations manifest cathepsin's significance in skin physiology as followed: CatD/CatL/CatV maintain normal epidermal differentiation and intact barrier;CatB/CatD/CatG/CatK keep the homeostasis of extracellular matrix (ECM); CatV insure of normal development and growth cycle of hair follicle. Those studies have been deepen in cell signals and gene regulations, and increased the understanding about the regulation of normal skin physiology. It's also possible to apply to the gene therapy field in the future.关键词
组织蛋白酶/表皮屏障/真皮细胞外基质/毛囊Key words
cathepsin/epidermal barrier/extracellular matrix/hair follicle引用本文复制引用
易文娟..组织蛋白酶参与皮肤生理的研究进展[J].临床与病理杂志,2017,37(9):1950-1953,4.基金项目
国家自然科学基金(81371717).This work was supported by the National Natural Science Foundation of China(81371717). （81371717）
