广西医科大学学报2017，Vol.34Issue(10)：1428-1431,4.DOI:10.16190/j.cnki.45-1211/r.2017.10.008
冠心病患者血清PAPP-A和sCD40L水平在诊断冠状动脉粥样硬化易损斑块中的价值分析
The diagnostic value of serum PAPP-A and sCD40L levels for coronary vulnerable plaque
摘要
Abstract
Objective:To investigate the diagnostic value of serum pregnancy associated plasma protein (PAPP-A) and soluble cell differentiation antigen 40 ligand (sCD40L) levels for coronary vulnerable plaque.Methods:304 patient with coronary heart disease (CHD)admitted in our hospital from November 2011 to November 2014 were selected.All patients received PAPP-A and sCD40L detection and coronary CT angioplasty (CTA).The value of PAPP-A and sCD40L in the diagnosis of coronary atherosclerotic plaques was analyzed.Results:Of 304 patients,105 cases were indentified with vulnerable plaques.Patients with vulnerable plaques had higher levels of PAPP-A and sCD40L than those without (P＜ 0.05).ROC curve showed that the sensitivity and specificity of PAPP-A were respectively 92.2％ and 87.3％ in the diagnosis of coronary vulnerable plaque,with a cut-off value of 0.9 tg/L.The sensitivity and specificity of sCD40L were respectively 89.0％ and 83.1％,with a cut-offvalue of 8.0 mg/L.The area under the ROC curve(AUC)of PAPP-A(0.902) was higher than that of sCD40L (0.812) (P＜ 0.05).The multivariate logistic regression analysis revealed that PAPP-A ＞ 0.9 μg/L and sCD40L ＞ 8.0 mg/L were independent risk factors for coronary vulnerable plaque (OR=2.49,95％ CI:1.15-5.36,P=0.01;OR=1.97,95％ CI:1.03-3.16,P=0.03).Conclusions:The levels of PAPP-A and sCD40L in serum were significantly increased in patients with coronary vulnerable plaques.PAPP-A and sCD40L could be the important predictors for coronary vulnerable plaque in patients with CHD,and PAPP-A was more valuable.关键词
易损斑块/PAPP-A/sCD40L/CT血管造影Key words
vulnerable coronary plaques/PAPP-A/sCD40L/computed CT angiography分类
医药卫生引用本文复制引用
朱汉华,谈礼武,阳维德,郑萍,黄晓明,布桂林,苗颖,马小燕,罗秀峰,陈锋..冠心病患者血清PAPP-A和sCD40L水平在诊断冠状动脉粥样硬化易损斑块中的价值分析[J].广西医科大学学报,2017,34(10):1428-1431,4.基金项目
广西医疗卫生重点科研课题资助项目(No.重2011020) （No.重2011020）
