广西医科大学学报2017，Vol.34Issue(10)：1453-1455,3.DOI:10.16190/j.cnki.45-1211/r.2017.10.015
神经节苷脂对脑室周围白质软化早产儿血浆一氧化氮合酶、白介素-1β及肿瘤坏死因子-α水平的影响
Influence of ganglioside on plasma nitric oxide synthase, interleukin-1β and tumor necrosis factor-α levels in premature infants with periventricular leukomalacia
张丽 1包晓玲1
作者信息
- 1. 陕西省渭南市妇幼保健院新生儿科,渭南050081
- 折叠
摘要
Abstract
Objective:To analyze the influence on plasma inducible nitric oxide synthase (iNOS),interleukin-1β (IL-1β) and tumor necrosis factor-αr (TNF-α) levels in premature infants with periventricular leukomalacia (PVL).Methods:The clinical data of 50 premature infants with PVL in our hospital from July 2013 to July 2016 were retrospectively analyzed.The infants were divided into two groups:the control group (23 cases)in which the infants received routine treatment and rehabilitation training with addition of cerebrolysin,and the study group in which the infants treated as the control group with addition of GM-1.The response rate and plasma iNOS,IL-1β and TNF-α concentrations were compared.Results:The response rate of study group was significantly higher than that of control group (P＜ 0.05).After treatment,plasma iNOS,IL-1β and TNF-α concentrations of study group were significantly lower than those of control group (P＜0.05).Conclusions:The mechanism of GM-1 in treatment of premature infants with PVL might be related to inhibiting the release of inflammatory cytokines,reducing iNOS activity and the neurotoxicity of NO.关键词
神经节苷脂/早产儿/脑室周围白质软化/诱导型一氧化氮合酶Key words
ganglioside/preterm infants/perivetricular leukomalacia/inducible nitric oxide synthase分类
医药卫生引用本文复制引用
张丽,包晓玲..神经节苷脂对脑室周围白质软化早产儿血浆一氧化氮合酶、白介素-1β及肿瘤坏死因子-α水平的影响[J].广西医科大学学报,2017,34(10):1453-1455,3.
