工业微生物2017，Vol.47Issue(5)：59-65,7.DOI:10.3969/j.issn.1001-6678.2017.05.013
一氧化氮在细菌抗药性和生物膜形成中的分子作用
Progress in molecular functions of nitric oxide in bacterial resistance mechanisms and biofilm formation
摘要
Abstract
Nitric oxide (NO) is a gaseous signal molecule with functions of adjusting vascular tension,inducing apoptosis of tumor cell and reducing botanic maturity.The latest researches demonstrate that NO can protect bacterial cells by limiting the intake of antibiotics,whereas,NO also can kill bacteria at high concentration.NO affects the bacterial biofilms formation mainly in three ways:two-component systems,c-di-GMP and quorum sensing.However,different bacteria exhibits different NO effects.In this paper the molecular functions of NO on the bacterial resistance mechanisms and biofilms formation were mainly introduced,and new directions for the development of NO research were also prospected.关键词
一氧化氮/杀菌剂/抗药性/生物膜/分子作用Key words
nitric oxide/antibiotic agents/resistance/bacterial biofilm/molecular functions引用本文复制引用
王颖思,周刚,彭红,谢小保,黄小茉,施庆珊..一氧化氮在细菌抗药性和生物膜形成中的分子作用[J].工业微生物,2017,47(5):59-65,7.基金项目
国家自然科学青年基金项目(No.31500036),广东省自然科学基金项目(No.2015A030313713). （No.31500036）
