海南医学院学报2017，Vol.23Issue(17)：2328-2330,2334,4.DOI:10.13210/j.cnki.jhmu.20170906.015
米力农辅助治疗对慢性心衰患者心功能、心肌重构、RAAS系统活性的影响
Effect of the adjuvant milrinone therapy on cardiac function,myocardial remodeling and RAAS system activity in patients with chronic heart failure
摘要
Abstract
Objective:To explore the effect of the adjuvant milrinone therapy on cardiac function,myocardial remode-ling and RAAS system activity in patients with chronic heart failure.Methods:A total of 110 patients with chronic heart failure who were treated in the hospital were divided into control group (n =55)and observation group (n =55)by random number table method.Control group received conventional therapy for chronic heart failure,and the observation group received milri-none on the basis of conventional therapy.The differences in ultrasound cardiac function and myocardial remodeling index levels as well as serum RAAS index contents were compared between the two groups before and after treatment.Results:Before treatment,the differences in ultrasound cardiac function and myocardial remodeling index levels as well as serum RAAS index contents were not statistically significant between the two groups (P > 0.05 ).After treatment,CO and SV levels of both groups of patients were significantly higher than those before treatment while LADd,LVEDd,LVPWT,IVST and LVMI lev-els as well as serum PRA,AngⅡ and ALD contents were significantly lower than those before treatment (P <0.05),and CO and SV levels of observation group were significantly higher than those of control group while LADd,LVEDd,LVPWT,IVST and LVMI levels as well as serum PRA,AngⅡ and ALD contents were significantly lower than those of control group (P <0.05).Conclusion:Adjuvant milrinone therapy can effectively enhance the cardiac function,inhibit the myocardial remodeling and decrease the RAAS system activity in patients with chronic heart failure.关键词
慢性心衰/米力农/心功能/心肌重构/RAASKey words
Chronic heart failure/Milrinone/Cardiac function/Myocardial remodeling/RAAS分类
医药卫生引用本文复制引用
陈静..米力农辅助治疗对慢性心衰患者心功能、心肌重构、RAAS系统活性的影响[J].海南医学院学报,2017,23(17):2328-2330,2334,4.基金项目
This study was supported by Medical Scientific Research Project of Sichuan Province (S 15089).四川省医学科研课题项目(S15089) （S 15089）
