海南医学院学报2017，Vol.23Issue(17)：2365-2368,4.DOI:10.13210/j.cnki.jhmu.20170906.007
盐酸羟考酮注射液超前镇痛对腹腔镜胆囊切除术患者血清炎性因子、神经递质指标及免疫功能的影响
Effect of oxycodone hydrochloride injection preemptive analgesia on serum inflammatory fac-tors,neurotransmitter index and immune function in patients with laparoscopic cholecystec-tomy
摘要
Abstract
Objective:To investigate the effect of oxycodone hydrochloride injection preemptive analgesia on serum in-flammatory factors,neurotransmitter index and immune function in patients with laparoscopic cholecystectomy.Methods:Ac-cording to random data table,113 patients undergoing laparoscopic cholecystectomy were divided into control group (n =57) and observation group (n =56),patients in the control group were treated with sufentanil citrate injection analgesia,and the observation group patients were given oxycodone hydrochloride injection analgesia,the levels of serum inflammatory factors [tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6 )],neurotransmitter index [5-hydroxy tryptamine (5-HT),P sub-stance]and immune function index [CD4 + ,CD8 + ,CD4 +/CD8 + ]of two groups between preoperative and postoperative 1 d were compared.Results:There were no significant differences in levels of TNF-α,IL-6,5-HT,P substance,CD4 + ,CD8 + and CD4 +/CD8 + between the two groups preoperative (P >0.05).Compared with the levels of the same group preoperative,post-operative 1 d,the levels of TNF-α,IL-6,5-HT,P substance,CD8 + were significantly increased,and levels in the observation group were significantly lower compared with the control group,the difference was statistically significant (P <0.05);Postop-erative 1 d,the levels of CD4 + ,CD4 +/CD8 + in the two groups were significantly lower than the preoperative level within the group,and the observation group was significantly higher than the control group (P <0.05 ).Conclusion:Oxycodone hydro-chloride injection preemptive analgesia in laparoscopic cholecystectomy can effectively reduce serum inflammatory factors and neurotransmitter index release,improve immune function,has an important clinical value.关键词
腹腔镜胆囊切除术/盐酸羟考酮注射液/炎性因子/神经递质/免疫功能Key words
laparoscopic cholecystectomy/oxycodone hydrochloride injection/inflammatory factor/neurotransmitter/immune function分类
医药卫生引用本文复制引用
刘婷,汤燕彬,贾暄东,吴文华,虞大为,周脉涛..盐酸羟考酮注射液超前镇痛对腹腔镜胆囊切除术患者血清炎性因子、神经递质指标及免疫功能的影响[J].海南医学院学报,2017,23(17):2365-2368,4.基金项目
It is supported by General Program of Natural Science Foundation in Jiangsu Province (BK2015127).江苏省自然科学基金面上项目 (BK2015127) （BK2015127）
