海南医学院学报2017，Vol.23Issue(17)：2369-2372,2376,5.DOI:10.13210/j.cnki.jhmu.20170906.014
不同剂量右美托咪定对老年腹腔镜手术患者炎症因子、T淋巴细胞亚群的影响
Effects of different doses of dexmedetomidine on inflammatory factors and T lymphocyte sub-sets in elderly patients undergoing laparoscopic surgery
摘要
Abstract
Objective:To investigate the effects of different doses of dexmedetomidine on inflammatory factors and T lymphocyte subsets in elderly patients undergoing laparoscopic surgery.Methods:From June 2016 to June 2017 in our hospital for laparoscopic surgery of 120 cases of elderly patients,were randomly divided into A group,B group,C group,D group of 30 cases,all patients underwent intravenous inhalational anesthesia,A,B,C in three groups were given dexmedetomidine be-fore induction of anesthesia.Fixed loading dose of 0.5μg/kg,after intubation respectively with dexmedetomidine 0.2 μg/(kg ·h),0.5 μg / (kg·h),0.8 μg / (kg·h)after continuous infusion to surgery,D group at the same time with the same vol-ume of physiological saline.Before induction of anesthesia (T0),24 h after operation (T1),72 h after operation (T2)of ve-nous blood interleukin-1 were measured beta (IL-1 beta),interleukin-2 receptor (sIL-2R)and interleukin-6 (IL-6),tumor necrosis factor alpha (TNF-alpha)and T lymphocyte subsets (CD3 + ,CD4 + ,CD8 + ).Results:The T1 of the 4 groups of sIL-2R,IL-6,IL-1 beta,TNF-alpha and T0 levels were significantly higher than (P <0.05),and A group,B group and C group than in D group (P <0.05),B group and C group than in A group (P <0.05),B group and C group had no significant differ-ence (P >0.05);group IL-1,sIL-2R,IL-6,TNF-beta and alpha level of T1 decreased significantly (P <0.05),and A group, B group and C group than in D group (P <0.05),B group and C group than in A group (P <0.05),B group and C group had no significant difference (P >0.05).T1 of the 4 groups of CD3 + ,CD4 + ,CD8 + ,CD4 +/CD8 + and T0 decreased significantly (P <0.05),and A group,B group and C group than in D group (P <0.05),B group and C group than in A group (P <0.05), B group and C group had no significant difference (P >0.05);T2 D group CD3 + ,CD4 + ,CD8 + ,CD4 +/CD8 + lower than T1 (P <0.05),and A group,B group,C group,CD3 + ,CD4 + ,CD8 + ,CD4 +/CD8 + higher than that of D group (P <0.05),B group,C group,CD3 + CD4 + ,CD8 + ,CD4 +/CD8 + higher than that of A group (P <0.05),B group,C group no significant difference (P >0.05).Conclusion:Dexmedetomidine can inhibit the inflammatory reaction and improve the immune function in elderly patients undergoing laparoscopic surgery,and the effect of middle and high dose is more significant.关键词
右美托咪定/老年腹腔镜手术/炎症因子/T淋巴细胞亚群Key words
Dexmedetomidine/Elderly laparoscopic surgery/Inflammatory factors/T lymphocyte subsets分类
医药卫生引用本文复制引用
张建新,刘冰冰,李彦君,彭晓静,郭平选..不同剂量右美托咪定对老年腹腔镜手术患者炎症因子、T淋巴细胞亚群的影响[J].海南医学院学报,2017,23(17):2369-2372,2376,5.基金项目
This study was supported by Key Science and Technology Research Plan Project of Health and Family Planning Commission of Hebei (20171429).河北省卫生和计划生育委员会重点科技研究计划项目(20171429) （20171429）
