海南医学院学报2017，Vol.23Issue(17)：2400-2403,4.DOI:10.13210/j.cnki.jhmu.20170906.016
超声萤火虫成像对甲状腺恶性结节微钙化的判断价值及其与结节内癌基因表达的相关性
The diagnostic value of MicroPure imaging for malignant thyroid nodule microcalcification and its correlation with the oncogene expression in nodules
摘要
Abstract
Objective:To study the diagnostic value of MicroPure imaging for malignant thyroid nodule microcalcifica-tion and its correlation with the oncogene expression in nodules.Methods:Patients with thyroid nodules confirmed by ultra-sound in Dongtai People's Hospital between June 2014 and October 2016 were selected and divided into those with malignant thyroid nodules and benign thyroid nodules according to the pathological results,and MicroPure imaging technology was used to judge the microcalcification and further divide the malignant thyroid nodules into microcalcification (+)and microcalcifica-tion (-).The biopsy tissue was collected to detect the expression of cyclin,cell invasion molecules and angiogenesis mole-cules.Results:CyclinD1,CyclinE,MCM7,MMP2,MMP13,Vimentin,N-cadherin,Twist,HIF-1α,VEGF-C,VEGFR-2, VEGFR-3,Ang-2 and Tie-2 expression in malignant thyroid nodules of microcalcification (+)group and microcalcification(-)group were significantly higher than those of benign group while CyclinG2 and P53 expression were significantly lower than those of benign group;CyclinD1,CyclinE,MCM7,MMP2,MMP13,Vimentin,N-cadherin,Twist,HIF-1α,VEGF-C, VEGFR-2,VEGFR-3,Ang-2 and Tie-2 expression in malignant thyroid nodules of microcalcification (+)group were signifi-cantly higher than those of microcalcification (-)group while CyclinG2 and P53 expression were significantly lower than those of microcalcification (-)group.Conclusion:Malignant thyroid nodule microcalcification detected by MicroPure imaging has a good correlation with cancer cell proliferation,invasion and angiogenesis.关键词
甲状腺癌/超声萤火虫成像/微钙化/增殖/侵袭/血管新生Key words
Thyroid cancer/MicroPure imaging/Microcalcification/Proliferation/Invasion/Angiogenesis分类
医药卫生引用本文复制引用
刘福娟..超声萤火虫成像对甲状腺恶性结节微钙化的判断价值及其与结节内癌基因表达的相关性[J].海南医学院学报,2017,23(17):2400-2403,4.基金项目
This study was supported by Project of Science and Technology Department of Jiangsu Province (BE2012617).江苏省科技厅资助项目(BE2012617) （BE2012617）
