海南医学院学报2017，Vol.23Issue(17)：2412-2415,4.DOI:10.13210/j.cnki.jhmu.20170906.010
结直肠癌患者术后化疗所致焦虑情绪与内分泌紊乱、免疫应答的相关性研究
Correlation of the anxiety caused by postoperative chemotherapy with endocrine disorder and immune response in patients with colorectal cancer
摘要
Abstract
Objective:To study the correlation of the anxiety caused by postoperative chemotherapy with endocrine dis-order and immune response in patients with colorectal cancer.Methods:110 patients who received radical operation for colorec-tal cancer and postoperative chemotherapy in the hospital between August 2014 and December 2016 were divided into the non-anxiety group (SAS<50 points)(n =29),mild-to-moderate anxiety group (50≤SAS≤69)(n =63)and severe anxiety group (SAS≥70 points)(n = 18)according to self-rating anxiety scale (SAS)score after one course of chemotherapy.The differ-ences in the levels of RAAS indexes,monoamine neurotransmitters,Th1/Th2 cytokines and Th17/Treg cytokines were com-pared among three groups of patients before and after chemotherapy.Results:Before chemotherapy,the differences in serum levels of RAAS indexes,monoamine neurotransmitters,Th1/Th2 cytokines and Th17/Treg cytokines were not statistically significant among the three groups of patients (P >0.05).After one course of chemotherapy,serum RAAS indexes REN,AngⅡ and ALD levels of mild-to-moderate anxiety group and severe anxiety group were higher than those of non-anxiety group;monoamine neurotransmitters NE and DA levels were higher than those of no anxiety group;serum IL-2 level was higher than that of non-anxiety group while IL-4 level was lower than that of non-anxiety group;serum IL-17 level was higher than of non-anxiety group while IL-10 was lower than that of non-anxiety group;the changes in serum levels of the above indexes of severe anxiety group were greater than those of mild-to-moderate anxiety group (P <0.05).Conclusion:The anxiety caused by post-operative chemotherapy in patients with colorectal cancer can directly lead to the endocrine disorder and the decrease of cellular immune function,and the negative changes increase with the aggravation of anxiety.关键词
结直肠癌/焦虑/内分泌紊乱/免疫应答Key words
Colorectal cancer/anxiety/endocrine disorder/immune response分类
医药卫生引用本文复制引用
张欣..结直肠癌患者术后化疗所致焦虑情绪与内分泌紊乱、免疫应答的相关性研究[J].海南医学院学报,2017,23(17):2412-2415,4.基金项目
It is supported by Science Research Foundation Project of Sichuan Health and Family Planning Bureau (201110505).四川省卫生厅科研基金资助项目(201110505) （201110505）
