海南医学院学报2017，Vol.23Issue(17)：2431-2433,2437,4.DOI:10.13210/j.cnki.jhmu.20170906.029
丹红注射液联合奥扎格雷钠对老年急性脑梗死患者血清IL-8、TNF-α、VEGF、TBIL及NSE的影响
Effect of danhong injection combined with ozagrel on serum IL-8,TNF-α,VEGF,TBIL and NSE in old patients with acute cerebral infarction
摘要
Abstract
Objective:To study the effect of danhong injection combined with ozagrel on serum IL-8,TNF-α,VEGF, TBIL and NSE in old patients with acute cerebral infarction.MethodsA total of 100 old patientswith acute cerebral infarction in our hospital from August 2014 to December 2016 were enrolled in this study.The subjects were divided into the control group (n =50)and the treatment group (n = 50)randomly.The control group were treated withozagrel,the treatment group were treated withdanhong injection combined with ozagrel,and both the two groups were treated for 14 days.The serum IL-8, TNF-α,VEGF,TBIL and NSEof the two groups before and after treatment were compared.Results There were no significantly differences of the serumIL-8,TNF-α,VEGF,TBIL and NSE of the two groups beforetreatment (P >0.05).The serum IL-8, TNF-α,NSE levels of the two groups after treatment were significantly lower than before treatment (P <0.05 ),the serum VEGF,TBIL levels of the two groups after treatment were significantly higher than before treatment (P <0.05),and that of the treatment group after treatment were significantly better than the control group (P <0.05).ConclusionDanhong injection combined with ozagrelcan significantly reduce the serum IL-8,TNF-α,NSE levels,improvethe serum VEGF,TBIL levels, and reduce inflammation,promote the nerve functional recovery of the old patients with acute cerebral infarction,and it was worthy clinical application.关键词
丹红注射液/奥扎格雷钠/急性脑梗死/白细胞介素8/肿瘤坏死因子α/血管内皮生长因子/胆红素/神经元特异性烯醇化酶Key words
Danhong injection/Ozagrel/Acute cerebral infarction/IL-8/TNF-α/VEGF/TBIL/NSE分类
医药卫生引用本文复制引用
李玲,张艳..丹红注射液联合奥扎格雷钠对老年急性脑梗死患者血清IL-8、TNF-α、VEGF、TBIL及NSE的影响[J].海南医学院学报,2017,23(17):2431-2433,2437,4.基金项目
It is supported by Science and Technology Development Plan Funded Project of Wuhan City (201260523185).武汉市科技攻关计划资助项目(201260523185) （201260523185）
