海南医学院学报2017，Vol.23Issue(17)：2438-2441,4.DOI:10.13210/j.cnki.jhmu.20171019.001.
阿替普酶溶栓治疗对脑梗死患者神经损伤及血清细胞因子的影响
Effect of alteplase thrombolysis on nerve injury and serum cytokines in patients with cerebral infarction
摘要
Abstract
Objective:To study the effect of alteplase thrombolysis on nerve injury and serum cytokines in patients with cerebral infarction.Methods:Patients with acute cerebral infarction who received thrombolytic therapy in Dongfang Hospital between May 2014 and October 2016 were retrospectively analyzed,and according to the different ways of thrombolysis,they were divided into rt-Pa group and UK group who accepted alteplase and urokinase thrombolysis respectively.Serum levels of nerve injury markers,nerve cytokines and inflammatory cytokines were detected before as well as 1d and 7d after thrombolytic therapy.Results:1d and 7d after thrombolysis,serum nerve injury markers NSE,S100B,MDA and 8-OHdG as well as in-flammatory cytokines IL-1β,IL-18,TNF-αand sVCAM-1 levels of both groups of patients were significantly lower than those before treatment while nerve cytokines BDNF,NGF and VEGF levels were significantly higher than those before treatment, and serum nerve injury markers NSE,S100B,MDA and 8-OHdG as well as inflammatory cytokines IL-1β,IL-18,TNF-αand sVCAM-1 levels of rt-Pa group were significantly lower than those of UK group while nerve cytokines BDNF,NGF and VEGF levels were significantly higher than those of UK group.Conclusion:Alteplase thrombolysis for acute cerebral infarction can re-duce nerve injury,improve neurotrophic state,and inhibit inflammatory response.关键词
急性脑梗死/阿替普酶/神经损伤/细胞因子/炎症反应Key words
Acute cerebral infarction/alteplase/nerve injury/cytokine/inflammatory response分类
医药卫生引用本文复制引用
周琴,魏天星,余飞,佘华,张津..阿替普酶溶栓治疗对脑梗死患者神经损伤及血清细胞因子的影响[J].海南医学院学报,2017,23(17):2438-2441,4.基金项目
It is supported by General Program of National Natural Youth Project (81471281).国自然青年项目面上项目(81471281) （81471281）
