解放军医药杂志2017，Vol.29Issue(10)：106-109,4.DOI:10.3969/j.issn.2095-140X.2017.10.027
尤瑞克林对急性进展性脑梗死患者血管内皮功能及血清炎性细胞因子的影响
Effects of Urinary Kallidinogenase on Vascular Endothelial Function and Serum Inflammatory Cytokines of Pa-tients with Acute Progressive Cerebral Infarction
摘要
Abstract
Objective To investigate effects of Urinary Kallidinogenase on vascular endothelial function and ser-um inflammatory cytokines of patients with acute progressive cerebral infarction. Methods Clinical data of 80 patients with acute progressive cerebral infarction admitted during February 2014 and October 2016 was retrospectively analyzed, and the patients were divided into observation group and control group ( n =40 for each group ) according to different treatment methods. Curative effects and changes of tumor necrosis factor-α ( TNF-α) , high sensitive C-reactive protein ( hs-CRP) , interleukin-1 ( IL-1 ) , endothelin-1 ( ET-1 ) , nitric oxide ( NO ) and vascular endothelial growth factor ( VEGF) before and after treatment were observed in two groups. Results In observation group, the total effective rate was significantly higher, and the NIHSS score after treatment was significantly lower than those in control group ( P<0. 05). TNF-α, hs-CRP and IL-1 levels after treatment were significantly lower than those before treatment in two groups, and the levels in observation group were significantly lower than those in control group (P<0. 05). After treat-ment ET-1 and VEGF levels were significantly higher, while NO levels were significantly lower than those before treat-ment in the two groups, and the improved conditions in observation group were significantly better than those in control group (P<0. 05, P<0. 01). Conclusion Urinary Kallidinogenase in treatment of patients with acute progressive cere-bral infarction can achieve good effectiveness, effectively reduce inflammatory response and improve the prognosis.关键词
尤瑞克林/脑梗死/内皮,血管:炎性因子Key words
Urinary kallidinogenase/Brain infarction/Endothelium/vascular/Inflammatory cytokines分类
医药卫生引用本文复制引用
康蓓,慕生枝..尤瑞克林对急性进展性脑梗死患者血管内皮功能及血清炎性细胞因子的影响[J].解放军医药杂志,2017,29(10):106-109,4.基金项目
陕西省社会发展科技攻关项目(2016SF-168) （2016SF-168）
