河北医学2017，Vol.23Issue(10)：1585-1588,4.DOI:10.3969/j.issn.1006-6233.2017.10.001
重症颅脑损伤患者血清中CRP和PCT水平与急性呼吸衰竭病情的关系
Relationship between Serum CRP and PCT Levels and Acute Respiratory Failure in Patients with Severe Craniocerebral Injury
摘要
Abstract
Objective:To study the relationship between serum C-reactive protein (CRP) and procalcitonin (PCT) levels in patients with severe craniocerebral injury and acute respiratory failure. Methods: From May 2015 to April 2016,77 patients with severe craniocerebral injury were selected. According to the results of laboratory examination and clinical features,the patients were divided into acute respiratory failure group (46 cases) and non-acute respiratory failure group (31cases). The levels of serum CRP and PCT were compared between the two groups at 1d,3d,5d and 7d after admission,and the specificity,sensitivity and area under the ROC curve (AUC) were compared between CRP and PCT. Results: The levels of serum CRP in the two groups were increased at 1d,3d,5d and 7d after admission,the level of PCT in the patients with acute respiratory failure was increased at 1d,3d,5d and 7d after admission,the levels of serum CRP and PCT in the patients with acute respiratory failure were higher than those in the non-acute respiratory failure group at 1d,3d,5d and 7d after admission,there was significant difference between the two groups,between the two groups at different time points (P <0.05). Patients with severe craniocerebral injury using serum CRP,PCT combined detection in parallel and diagnosis of acute respiratory failure specificity of 0.773,the sensitivity was 0.817,and the AUC was 0.873,which was significantly higher than that of serum CRP and PCT alone. Conclusion:The levels of CRP,PCT and acute respiratory failure in patients with severe craniocerebral injury are closely related. The combined detection of serum CRP and PCT can improve the diagnostic value of acute re-spiratory failure in patients with severe craniocerebral injury.关键词
重症颅脑损伤/C-反应蛋白/急性呼吸衰竭Key words
Severe craniocerebral injury/C-reactive protein/Acute respiratory failure引用本文复制引用
廖环,崔大明,李明,许峰峰,李政卫..重症颅脑损伤患者血清中CRP和PCT水平与急性呼吸衰竭病情的关系[J].河北医学,2017,23(10):1585-1588,4.基金项目
上海市科委基金项目,(编号:0264119524) （编号:0264119524）
