河北医学2017，Vol.23Issue(10)：1646-1649,4.DOI:10.3969/j.issn.1006-6233.2017.10.018
肾病综合征患者外周血T细胞亚群及血清脂联素水平与患者激素治疗效果的关系
The Relationship between Peripheral Blood T Lymphocyte Subsets Serum Adiponectin Levels and the Effect of Hormone Therapy in Patients with Nephrotic Syndrome
摘要
Abstract
Objective:To investigate the relationship between peripheral blood T lymphocyte subsets (Treg),serum adiponectin (APN) levels and the effect of hormone therapy in patients with nephrotic syn-drome. Methods: 80 cases of primary nephrotic syndrome patients were selected during May 2014 to May 2016 in our hospital.35 healthy volunteers as control group,all patients were detected in the serum adiponectin level in patients with T cell subsets and serum in all patients using standard hormone treatment,serum T cell subsets and serum lipid in the association between hormone levels and treatment effect and prognosis of pa-tients with hormone. Results:The levels of peripheral blood Treg cells in patients of the observation group was 4.25±1.32,which significantly lower than that in patients of the control group; The levels of APN, T helper cell 17 (Th17) and the ratio of Th17/Treg cells were 33.6±12.5 mg/L,1.63± 0.26,0.51 ± 0.07,which sig-nificantly higher than that in the control group (P<0.05). Patients were divided into low and high levels of hormone-sensitive therapy based on the numbers of Treg cells,and the results showed 38 cases of patients in the low-level group and 42 cases in high level group. Of them,19 cases (50%) and 26 cases (61.90%) in the low-level and high-level groups respectively,were sensitive to hormone therapy. Patients were divided in-to low-level and high-level groups based on the median of serum APN and the results showed 39 and 41 cases of patients that sensitive to hormone therapy. Of them,19 cases (48.70%) and 26 cases (63.41%) in the low-level and high-level groups respectively,were sensitive to hormone therapy. The difference was not statisti-cally significant,P>0. 05. Conclusion: The number of Treg cells and serum adiponectin levels were closely related to the effect of hormone therapy.关键词
肾病综合征/Treg/脂联素/激素/效果Key words
Nephrotic syndrome/Treg/Adiponectin/Hormone/Effect引用本文复制引用
朱磊,解德琼,张臣丽,吴娅琳..肾病综合征患者外周血T细胞亚群及血清脂联素水平与患者激素治疗效果的关系[J].河北医学,2017,23(10):1646-1649,4.基金项目
四川省卫生厅基金资助项目,(编号:SC081920) （编号:SC081920）
