摘要
Abstract
Objective To investigate the correlations of vitamin B12 and folic acid and homocysteine with Alzheimer's dis-ease (AD).Methods Serum vitamin B12 and folic acid levels were determined by chemiluminescence microparticle immunoassay in 95 elderly dementia patients ≥ 50 years old and 76 cognitive normal subjects (normal control group).The low levels of vitamin B12 and folic acid and homocysteine as high-risk factors for AD were analyzed.Cognitive function was evaluated with comprehen-sive neuropsychological tests,such as Chinese Version of Mini Mental State Examination (CMMSE).Pearson's correlation analysis was performed to evaluate the relationship among serum vitamin B12 ,folic acid,homocysteine,age,education year,and cognitive function in all groups.Logistic regression was used to evaluate the association of vitamin B12 ,folic acid and homocysteine with AD.Results A total 96 patients with AD were determined.There were 153 cases of folic acid in the 171 cases,including 79 in normal group (51.63%)and 74 cases in the experimental group (43.27%).The normal number of vitamin B12 was found in 124 cases,including 60 in normal group (48.39%),and 64 cases in the experimental group (51.61%).101 homocysteine was normal. Among them,51 cases (50.50%)and 50 cases (49.50%)were normal.Vitamin B12 ,folic acid or homocysteine level had no correla-tion with CMMSE scores after covariates'adjustments (P >0.05 ).Low vitamin B12 level and folic acid was correlated with the risk of AD.Conclusion Vitamin B12 ,folic acid and homocysteine are not correlated with cognitive impairment.However,low vita-min B12 level and folic acid may be correlated with an increased risk for AD;Low levels of homocysteine may reduce AD risk by some mechanism.关键词
维生素B12/叶酸/同型半胱氨酸/阿尔茨海默症/认知功能障碍Key words
Vitamin B12/Folic acid/Homocysteine/Alzheimer's disease/Cognitive impairment分类
医药卫生
