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低温光聚合制备可降解多孔支架及其性能

王克敏 朱奇凡 俞强

常州大学学报(自然科学版)2017,Vol.29Issue(5):35-45,11.
常州大学学报(自然科学版)2017,Vol.29Issue(5):35-45,11.DOI:10.3969/j.issn.2095-0411.2017.05.006

低温光聚合制备可降解多孔支架及其性能

Preparation and Properties of Biodegradable Crosslinking Porous Scaffolds Materials via Low Temperature Phase Separation Photopolymerization

王克敏 1朱奇凡 1俞强1

作者信息

  • 1. 常州大学 材料科学与工程学院,江苏 常州 213164
  • 折叠

摘要

Abstract

The double bond-terminated polycaprolactone dimethacrylate (PCLDMA)and the double-capped polylactic acid dipropyl methacrylate (PLADMA)were synthesized.The biodegradable porous scaffolds were prepared by low temperature photopolymerization induced phase separation.The results of scanning electron microscopy showed the higher the solvent content,the higher the porosity and the larger the pore size.The size of the pores decreases gradually as the cooling temperature decreases,the faster the cooling rate,the smaller the porosity and pore size.The thermal stability of PCLDMA por-ous scaffold was higher than that of PLADMA.Two kinds of materials in PBS solution were stable and slow degradation in vitro.The mechanical properties of PLADMA porous scaffold have high com-pressive strength and elastic modulus,and the brittleness of PCLDMA scaffold has low compressive strength and elastic modulus,but possessed good toughness and some deformation recovery.

关键词

聚乳酸/聚己内酯/低温光聚合/多孔支架

Key words

polylactic acid/polycaprolactone/low temperature photopolymerization/porous scaffold

分类

化学化工

引用本文复制引用

王克敏,朱奇凡,俞强..低温光聚合制备可降解多孔支架及其性能[J].常州大学学报(自然科学版),2017,29(5):35-45,11.

基金项目

国家自然科学基金资助项目(21304011). (21304011)

常州大学学报(自然科学版)

2095-0411

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