检验医学与临床2017，Vol.14Issue(20)：3035-3037,3.DOI:10.3969/j.issn.1672-9455.2017.20.022
丹参川芎嗪注射液治疗重症急性胰腺炎的临床研究
Clinical research on treating severe acute pancreatitis with Miltriorrhiza and Ligustrazine jection
李聃 1刘召明 1张华 1崔传宝 1张平平1
作者信息
- 1. 齐鲁医药学院药学院,山东淄博255213
- 折叠
摘要
Abstract
Objective To investigate the effects of Salvia Miltiorrhiza and Ligustrazine Injection on serum cytokines and immune function in the patients with severe acute pancreatitis(SAP).Methods One hundred and twenty cases of SAP in the hospital from 2015 to 2016 were divided into the observation group(n=60)and control group(n=60)according to the random number table. Both groups were treated with conventional symptomatic treatment.The control group was simultaneously given with intravenous infusion of omeprazole,while on this basis the observation group used Ligustrazine Injection treatment.The clinical treatment effects were compared between the two groups.The levels of serum inflammatory factors and immune function in the two groups were compared between before and after treatment.Results The total effective rate of the observation group was higher than that of the control group.The incidence rate of multiple organ dysfunction syndrome(MODS),abdominal pressure increase and hy-peramylasemia was lower than that of the control group,the difference was statistically significant(P<0.05);while the adverse drug reaction rate had no statistically significant difference between the two groups(P>0.05).The levels of serum interleukin-6, IL-8 and tumor necrosis factor-α after treatment in the observation group were lower than those in the control group with statistical difference(P<0.05);The levels of CD3+,CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Ligustrazine Injection can effectively decrease the level of serum inflammatory cytokines in elderly patients with SAP and increases their immune function and improves their prognosis.关键词
丹参川芎嗪注射液/重症急性胰腺炎/炎症因子/免疫功能Key words
Salvia Miltiorrhiza and Ligustrazine Injection/severe acute pancreatitis/inflammatory factor/immune func-tion引用本文复制引用
李聃,刘召明,张华,崔传宝,张平平..丹参川芎嗪注射液治疗重症急性胰腺炎的临床研究[J].检验医学与临床,2017,14(20):3035-3037,3.
