检验医学与临床2017，Vol.14Issue(20)：3056-3058,3.DOI:10.3969/j.issn.1672-9455.2017.20.030
小剂量米非司酮对子宫肌瘤患者雌、孕激素水平、子宫及瘤体体积的影响
Effet of low dose mifepristone on estrogen,progesterone,uterine volume and tumor volume in patients with uterine fibroid
高艳民 1孙小芳 1刘连臣 1王秀兰 2王玖珍 3张小胖1
作者信息
- 1. 河北省任丘市妇幼保健院妇产科 062550
- 2. 河北省沧州市海兴医院妇产科 061000
- 3. 河北省唐山市丰南中医医院妇产科 063000
- 折叠
摘要
Abstract
Objective To investigate the effect of low dose mifepristone in the patients with uterine fibroid and its effects on es-trogen,progesterone and tumor volume.Methods A total of 152 patients with uterine fibroid in our hospital from December 2013 to October 2016 were selected and randomly divided into the control group(n=76)and observation group(n=76)according to the random number table method.The control group used the Julisanjie Tablet treatment,while the observation group was treated by combining with small dose of Mifepristone Tablet.ELISA was used to detect the estrogen receptor,progesterone receptor and EG-FR level.The clinical curative effects and influences on estrogen receptor,progesterone receptors and EGFR were compared between the two groups.Results The vascular endothelial growth factor and tumor necrosis factor alpha levels after treatment in the obser-vation group were lower than those in the control group with statistical difference(P<0.05);the estrogen,progesterone,LH and FSH levels had no statistically significant difference between the two groups before treatment(P>0.05),the estrogen,progesterone and LH and FSH levels after 3-month treatment in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05);the uterine volume after treatment in the observation group was larger than that in the con-trol group,the uterine myoma volume after treatment in the observation group was less than that in the control group,the difference were statistically signiticant(P<0.05);the total effective rate had statistical difference between the two groups(P<0.05).Conclu-sion Low dose mifepristone for treating uterine fibroid can improve the levels of estrogen receptor,progesterone receptor and EG-FR,guides the clinical treatment and is worth promotion and application.关键词
小剂量米非司酮/子宫肌瘤/雌、孕激素水平/子宫体积/瘤体体积Key words
low dose mifepristone/uterine fibroid/estrogen receptor/progesterone receptor/uterine volume/tumor volume引用本文复制引用
高艳民,孙小芳,刘连臣,王秀兰,王玖珍,张小胖..小剂量米非司酮对子宫肌瘤患者雌、孕激素水平、子宫及瘤体体积的影响[J].检验医学与临床,2017,14(20):3056-3058,3.
