检验医学与临床2017，Vol.14Issue(20)：3061-3063,3.DOI:10.3969/j.issn.1672-9455.2017.20.032
蛛网膜下腔出血患者GFAP、S100B的表达与预后相关性研究
Correlation between glial fibrillary acidic protein and S100B protein expression with prognosis in patients with subarachnoid hemorrhage
郝芳芳 1贺婕 1孙志华 1吴宝水 1肖丽萍1
作者信息
- 1. 河北省廊坊市中国石油天然气集团公司中心医院神经内科 065000
- 折叠
摘要
Abstract
Objective To determine the levels of serum glial fibrillary acidic protein(GFAP)and S100B protein in the patients with subarachnoid hemorrhage(SAH),and to investigate their correlation with early brain injury and prognosis in SAH.Methods The SAH patients treated in the hospital from September 2012 to September 2015 were selected as the case group and the individu-als undergoing physical examination served as the control group.The levels of serum GFAP and S100B protein on 1,2,3,6 d after onset were detected by adopting the enzyme-linked immunosorbent assay.All cases were evaluated by using NIHSS at the corre-sponding time points.The cases of disease onset more than 6 months were performed the GOS scoring.Results The levels of serum GFAP and S100B protein on 1,2,3,6 d after onset had statistical difference between the case group and control group(P<0.05). The levels of serum GFAP and S100B protein after SAH were positively correlated with early cerebral injury after SAH and nega-tively correlated with prognosis,the difference was statistically significant(P<0.05).Conclusion The expression levels of serum GFAP and S100B can reflect the degree of early brain injury after SAH and provide a basis for the assessment of early brain injury after SAH and prognosis.关键词
胶质纤维酸性蛋白/S100B蛋白/珠网膜下腔出血/早期脑损伤Key words
glial fibrillary acidic protein/S100B protein/subarachnoid hemorrhage/early brain injury引用本文复制引用
郝芳芳,贺婕,孙志华,吴宝水,肖丽萍..蛛网膜下腔出血患者GFAP、S100B的表达与预后相关性研究[J].检验医学与临床,2017,14(20):3061-3063,3.
