首页|期刊导航|临床口腔医学杂志|GDF11通过激活Smad2/3信号通路抑制小鼠BMSCs骨向分化的体外研究

GDF11通过激活Smad2/3信号通路抑制小鼠BMSCs骨向分化的体外研究

朱彪焦婷赵刚梅稳郭希民郭红延向光大

临床口腔医学杂志2017，Vol.33Issue(10)：579-582,4.

临床口腔医学杂志2017，Vol.33Issue(10)：579-582,4.DOI:10.3969/j.issn.1003-1634.2017.10.001

GDF11通过激活Smad2/3信号通路抑制小鼠BMSCs骨向分化的体外研究

GDF11 inhibits osteoblast differentiation of mice-derived BMSCs via activating Smad2/3:a study in vitro

朱彪 ¹焦婷 ²赵刚 ³梅稳 ²郭希民 ²郭红延 ²向光大⁴

作者信息

1. 中国人民解放军武汉总医院内分泌与代谢科湖北武汉 430070
2. 南方医科大学研究生院广东广州 510515
3. 河北大学附属医院肿瘤科河北保定 071000
4. 武警总医院口腔医学中心北京 100039
折叠

摘要

Abstract

Objective:To investigate the effect of GDF11 on the osteoblast differentiation of BMSCs in vitro. Meth-ods:BMSCs were randomly divided into Vehi group and GDF11 group,after cultured in osteogenic differentiation medium, ALP activity,Von Kossa staining,qRT-PCR and Western blot were tested. Results:GDF11 decreased ALP activity and calci-um mineralization,reduced mRNA expression of osteogenic transcription factors by enhancing Samd2/3 signaling pathyway. Conclusion:GDF11 can inhibit BMSCs' osteoblast differentiation in vitro.

关键词

生长分化因子11(GDF11)/骨髓间充质干细胞/成骨细胞/组织工程骨

Key words

GDF11/BMSCs/Osteoblast/Tissue-engineered bone

分类

医药卫生

引用本文复制引用

朱彪,焦婷,赵刚,梅稳,郭希民,郭红延,向光大..GDF11通过激活Smad2/3信号通路抑制小鼠BMSCs骨向分化的体外研究[J].临床口腔医学杂志,2017,33(10):579-582,4.

基金项目

国家自然科学基金(81570730) （81570730）

临床口腔医学杂志

OACSTPCD

ISSN：1003-1634

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