临床误诊误治2017，Vol.30Issue(10)：94-97,4.DOI:10.3969/j.issn.1002-3429.2017.10.031
ⅠB2~ⅡB期宫颈癌新辅助化疗效果及敏感性影响因素分析
Effects and Sensitive Influencing Factors of Neoadjuvant Chemosensitivity in Treatment of Patients with Stage ⅠB2-ⅡB Cervical Cancer
摘要
Abstract
Objective To investigate effects and sensitive influencing factors of neoadjuvant chemotherapy ( NACT) in treatment of patients with stage ⅠB2-ⅡB cervical cancer. Methods A total of 100 patients with stage ⅠB2-ⅡB cervical cancer admitted during February 2013 and April 2016 underwent 1-3 period of NACT treatment and follow-up surgery treat-ment, and effects of NACT were observed. The patients were divided into effective and ineffective groups according to treat-ment effects for further analyzing sensitive influencing factors of NACT. Results The effective rate of 100 patients with NACT was 64. 00%. In effective group, follow-up surgery time was significantly shorter, and cervical deep stromal infiltration and lymph node metastasis rates were significantly lower than those in ineffective group (P<0. 05 or P<0. 01). Multiple factors analysis showed that tumor diameter equal or more than 4 cm, value of squamous cell carcinoma antigen equal or more than 4 ng/ml and value of platelet/lymphocyte absolute equal or more than 123. 7 were sensitive influencing factors of NACT in treatment of patients with cervical cancer. Conclusion Reasonable choice of indication and intervention of related factors af-fecting treatment sensitivity should be performed before NACT for patients with stage ⅠB2-ⅡB cervical cancer in order to im-prove chemotherapy effect and subsequently surgical treatment effect and improve prognosis of patients.关键词
宫颈肿瘤/放化疗,辅助/治疗结果/敏感性/影响因素分析Key words
Cervical cancer/Chemoradiotherapy/adjuvant/Treatment outcome:Sensitivity/Root cause analysis分类
医药卫生引用本文复制引用
蒋奉希,张力忆,桂定清..ⅠB2~ⅡB期宫颈癌新辅助化疗效果及敏感性影响因素分析[J].临床误诊误治,2017,30(10):94-97,4.基金项目
四川省卫生厅科研项目(150055) （150055）
