南京师大学报（自然科学版）2017，Vol.40Issue(3)：118-122,5.DOI:10.3969/j.issn.1001-4616.2017.03.017
一种水溶性酞菁纳米晶的制备及光敏活性研究
Preparation and Photodynamic Activity of a Water-Soluble Phthalocyanine Nanoparticle
摘要
Abstract
A novel water soluble nanocrystalline phthalocyanine(NNZnPc-NP)was prepared using reprecipitation method. The surface morphology,stability,singlet oxygen generation ability and photosensitive anticancer activity of it were studied by transmission electron microscopy(TEM),UV-Vis spectrophotometer and inverted fluorescence microscope.The results showed that the particle size of NNZnPc-NP is uniform,the dispersion is good,and it can be stable in aqueous solution. Besides,it also exhibits excellent singlet oxygen generation ability and photostability. The in vitro anticancer experiment results confirm that NNZnPc-NP can efficiently kill HeLa cells under the visible light irradiation. The above results indi-cate NNZnPc has good potential to be used as clinical photosensitizer for PDT.关键词
光动力疗法/锌酞菁/纳米晶/光敏抗肿瘤活性Key words
photodynamic therapy/zinc phthalocyanine/nanocrystalline/photosensitive anticancer activity分类
化学化工引用本文复制引用
周莉,赵光辉,周林,魏少华..一种水溶性酞菁纳米晶的制备及光敏活性研究[J].南京师大学报（自然科学版）,2017,40(3):118-122,5.基金项目
教师教学能力提升研究课题(90YAJ16018)、江苏省优势学科建设工程资助项目. （90YAJ16018）
