农药学学报2017，Vol.19Issue(5)：533-542,10.DOI:10.16801/j.issn.1008-7303.2017.0071
分子插件法及其在农药分子设计中的应用
The plug-in molecules method and its application in designing of novel agrochemicals
摘要
Abstract
The discovery of new agrochemicals is a time-consuming, costly and complex systematic project. The design of new agrochemical molecule is initial and the most important part of the project. In this review, the traditional design methods of agrochemicals were briefly summarized, and a new method, the plug-in molecules method, was presented on the basis of the practice of our group. Arylpyridinylmethanone and aryloxypyridinylethanone were used as two representatives of plug-in molecules. Their design and application in pesticides discovery were sketched out. The main advantage of this new method is that the pharmacophores and functional groups were modularized, which facilitates rapid derivation and screening, shortens the period of new agrochemicals discovery and meets the demand of fierce competition.关键词
分子插件/新农药创制/分子设计Key words
plug-in molecules/new agrochemicals discovery/molecular design分类
化学化工引用本文复制引用
车传亮,杨冬燕,万川,王家尧,刘雪莲,赵峰海,覃兆海..分子插件法及其在农药分子设计中的应用[J].农药学学报,2017,19(5):533-542,10.基金项目
"十二五"国家科技支撑计划资助项目 (2015BAK45B01). （2015BAK45B01）
