农药学学报2017，Vol.19Issue(5)：550-554,5.DOI:10.16801/j.issn.1008-7303.2017.0073
氯苯醚酰胺(Y13149)生物活性初步研究及水稻纹枯病菌对其敏感性基线的建立
Bioactivity of Y13149 and its sensitivity baseline of Rhizoctonia solani
摘要
Abstract
The bioactivity of Y13149,N-(2-(2,4-dichlorophenoxy) phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, a novel succinate dehydrogenase inhibitor discovered through pharmacophore-linked fragment virtual screening by Huazhong Normal University, was evaluated by the method of mycelial growth rate. Results indicated that it exhibited good inhibitory activities against 10 tested plant-pathogenic fungi with the EC50 of 0.008-15.25 mg/L and the highest inhibition rate was observed in the case ofRhizoctonia solani. However, Y13149 had lower activities againstPhytophthora capsici andPythium catenulatum. In field experiments, the control efficacy of Y13149 for the rice sheath blight disease is, on average, 79.6% at the dose of 75 g/hm2, which is comparable with that of trifuzamide (77.3% at the dose of 75 g/hm2). Further study suggested that the EC50 for the tested population (n = 125) ofR. solani collected from Zhejiang and Jiangsu Province fitted unimodal distribution and varied from 0.002 to 0.259 mg/L with the mean of (0.021 ± 0.008) mg/L, which could be adopted as the baseline sensitivity ofR. solani to Y13149 to monitor the sensitivity shift.关键词
氯苯醚酰胺/琥珀酸脱氢酶抑制剂/生物活性/立枯丝核菌/水稻纹枯病/敏感性基线Key words
Y13149/succinate dehydrogenase inhibitor (SDHIs)/bioactivity/Rhizoctonia solani/rice sheath blight/sensitivity baseline分类
农业科技引用本文复制引用
戴德江,魏方林,王琼伟,吴鉴艳,张传清..氯苯醚酰胺(Y13149)生物活性初步研究及水稻纹枯病菌对其敏感性基线的建立[J].农药学学报,2017,19(5):550-554,5.基金项目
浙江省重点研发项目 (2015C02G2010084) （2015C02G2010084）
浙江公益技术应用研究计划 (2016C32002) （2016C32002）
浙江省"三农六方"项目. （）
