山东医药2017，Vol.57Issue(38)：1-4,4.DOI:10.3969/j.issn.1002-266X.2017.38.001
慢性阻塞性肺疾病急性加重期患者血清GRO-α、MRpro-ADM水平变化及临床意义
Changes in levels of serum GRO-α and MRpro-ADM in patients with acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To observe the changes in levels of the serum growth-regulated oncogene-α(GRO-α) and mid-regional fragment of pro-adrenomedullin (MRpro-ADM) in patients with acute exacerbation of chronic obstructive pul-monary disease(AECOPD) and its clinical significance.Methods A total of 79 patients with AECOPD(AECOPD group) were collected. At the same time,60 patients with stable COPD (stable COPD group) and 60 healthy volunteers (control group) were randomly selected. The serum GRO-α levels of the three groups were detected by the enzyme-linked immunosorbent assay,and MRpro-ADM levels of three groups were detected by the time-resolved immunofluorescence as-say. And the forced expiratory volume in one second (FEV1 ),forced vital capacity (FVC),FEV1/FVC were measured. The correlation between serum GRO-α,MRpro-ADM,and lung function such as FEV1 ,FVC,and FEV1/FVC were ana-lyzed by Pearson product moment correlation analysis. The diagnostic value of GRO-α,MRpro-ADM for AECOPD were an-alyzed by the receiver operating characteristic(ROC) curve.Results The serum levels of GRO-α and MRpro-ADM in the AECOPD group and stable COPD group were higher than those of the control group,and the AECOPD group was higher than the stable COPD group (both P<0. 05). Compared with the control group,the levels of FEV1,FVC,and FEV1/FVC in the AECOPD group and stable COPD group were lower,and the AECOPD group was lower than the stable COPD group (all P<0. 05 ). The serum level of GRO-α was negatively correlated with FEV1 ,FVC,and FEV1/FVC (r =-0. 471,-0. 509,and -0. 511 respectively;all P<0. 05). The serum level of MRpro-ADM was negatively correlated with FEV1 ,FVC,and FEV1/FVC (r= -0. 539,-0. 517,and -0. 498;all P<0. 05). The area under the ROC curve (AUC)of serum GRO-α for predicting AECOPD was 0. 854,the best cut-off value was 109. 34 ng/L,and the sensitivity and the specificity were separately 0. 82 and 0. 91 with accuracy of 0. 83. The AUC of serum MRpro-ADM for predicting AECOPD was 0. 808,the best cut-off value was 1. 28 nmol/L,and the sensitivity and the specificity were 0. 75 and 0. 82, respectively,with the accuracy of 0.77.Conclusion The serum levels of GRO-α and MRpro-ADM in patients with AECO-PD significantly increase,which can be used as important markers for clinical diagnosis of AECOPD.关键词
急性加重期慢性阻塞性肺疾病/生长调节致癌基因-α/肾上腺髓质素前体中段肽/第一秒用力呼气容积/用力肺活量Key words
acute exacerbation of chronic obstructive pulmonary disease/growth-regulated oncogene-α/mid-regional fragment of pro-adrenomedullin/forced expiratory volume in first second/forced vital capacity分类
医药卫生引用本文复制引用
王艳娥,余波,丰莉娟,艾芬..慢性阻塞性肺疾病急性加重期患者血清GRO-α、MRpro-ADM水平变化及临床意义[J].山东医药,2017,57(38):1-4,4.基金项目
湖北省自然科学基金资助项目(2016CFB378). （2016CFB378）
