实用医学杂志2017，Vol.33Issue(18)：3035-3039,5.DOI:10.3969/j.issn.1006-5725.2017.18.014
螺旋断层放疗模式下非小细胞肺癌急性重度放射性食管炎的相关因素
Impact of dose volume parameters and clinical factors on severe acute radiation-induced esophagitis for NSCLC patients treated with tomotherapy
摘要
Abstract
Objective To identify clinical and dosimetric parameters from dose-volume histogram(DVH) relating with incidence of severe acute radiation-induced esophagitis(RE)in patients with non-small cell lung can-cer(NSCLC)underwent tomotherapy with concurrent or sequential chemotherapy. Methods Records about clini-cal information and treatment plan parameters from DVH of 62 NSCLC patients treated with tomotherapy were pro-spectively collected to assess the correlation to severe acute RE from January 2012 to December 2016. Results There were 24.2％patients developed grade 3 RE,grade 4 or 5 in 0％patients. Multivariate analysis indicated that concurrent chemotherapy,esophagus median dose and esophagus V25 and V55 were the influencing factors of RE. The incidence of low frequencies RE was correlated with sequential chemotherapy ,esophagus median dose < 49 Gy,esophagus V25 < 64％ ,V55 < 33％ and V60 < 15％. Conclusions For NSCLC patients treated with tomo-therapy and chemotherapy,the occurrence of acute RE was similar to that of other techniques. It is recommended to balance such parameters for optimizing treatment planning.关键词
非小细胞肺癌/螺旋断层放疗/放射性食管损伤/剂量体积直方图Key words
non-small cell lung cancer/tomotherapy/radiation-induced esophagitis/dose volume histograms引用本文复制引用
王彦,李志强,钟毓,张晋建,文婷,徐艳红,贾峻嵩,陈静,黎静..螺旋断层放疗模式下非小细胞肺癌急性重度放射性食管炎的相关因素[J].实用医学杂志,2017,33(18):3035-3039,5.基金项目
广东省省科技计划项目(编号:2013B021800051) （编号:2013B021800051）
