实用医学杂志2017，Vol.33Issue(18)：3092-3095,4.DOI:10.3969/j.issn.1006-5725.2017.18.029
低剂量长疗程糖皮质激素治疗急性呼吸窘迫综合征的效果及安全性研究
Efficacy and safety of long-term use of low dose glucocorticoids in acute respiratory distress syndrome
摘要
Abstract
Objective To explore the ef fi cacy and safety of long-term use of low dose glucocorticoids in acute respiratory distress syndrome (ARDS). Methods Fifty ARDS patients were randomly divided into two groups. The control group(25 patients)received non-invasive or invasive mechanical ventilation,antibiotics and support treatments. The glucocorticoids group(25 patients)received the same treatments plus long-term use of low dose glucocorticoids. Results The mortality in glucocorticoids group(32％(8/25))was much lower than that in the control group(60％(15/25))(P < 0.05). The ventilator-free days and organ failure-free days within 28d in glucocorticoids group were significantly higher than those in the control group (P < 0.05). The oxygenation index and the serum IL-8 levels in glucocorticoids group at 14d and 28d were higher than those in the control group(P<0.05). Compared to the control group ,long-term use of low dose glucocorticoids in ARDS did not increase fasting blood-glucose at 7d,gastrointestinal bleeding and hospital infections within 28d. Conclusions Long-term use of low dose glucocorticoids in ARDS could reduce the serum IL-8 levels and improve the prognosis.关键词
急性呼吸窘迫综合征/糖皮质激素/低剂量/疗效/安全性Key words
Acute respiratory distress syndrome/Glucocorticoids/Low dose/Efficacy/Safety引用本文复制引用
史家欣,李家树,李小美,郭祥君,张峰,杨俊发,张嫚,霍雯..低剂量长疗程糖皮质激素治疗急性呼吸窘迫综合征的效果及安全性研究[J].实用医学杂志,2017,33(18):3092-3095,4.基金项目
江苏省卫计委面上科研课题(编号:H201558) （编号:H201558）
国家自然科学基金(编号:81300052) （编号:81300052）
中国博士后科学基金(编号:2015M570420) （编号:2015M570420）
连云港市521工程资助项目 （）
连云港市科技局资助课题(编号:SH1401) （编号:SH1401）
