实用医学杂志2017，Vol.33Issue(19)：3235-3239,5.DOI:10.3969/j.issn.1006-5725.2017.19.021
心率控制对慢性心力衰竭患者炎症因子及心功能的影响
Influence of intensive heart rate control on inflammatory factor and cardiac function in patients with chronic heart failure
摘要
Abstract
Objective To investigate the influence of intensive heart rate control on inflammatory factor and cardiac function in patients with chronic heart failure. Methods From January 2015 to December 2015 ,a total of 120 CHF patients in New York Heart Association(NYHA)functional classes Ⅱ to Ⅳ were enrolled and randomized into treatment group(n=60)and control group(n=60). All the patients were in stable situation af-ter conventional drug treatment. The patients in treatment group underwent intensive heart rate control for target HR (55~60 beats/min)through adjusting the dose of metoprolol sustained-release tablets. The concentration of C-reac-tion protein(CRP),interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factorα(TNF-α)were de-tected before and after 6-month treatment. The resting heart rate and the concentration of brain natriuretic peptide (BNP),left ventricular ejection fracetion(LVEF),left ventricular end diastolic diameter(LVEDD)and left ven-tricular end systolic dimension(LVEDD)were measured at the start and 6-months after treatment. Results After 6-month treatment,the resting heart rate of the patients in the treatment group decreased significantly compared with that of the control group(P<0.001). Inflammatory factors(CRP,IL-1β,IL-6 and TNF-α)levels decreased significantly compared with that of control group (P < 0.05). The echocardiography parameters (LVEDD and LVESD)and the concentration of BNP of the patients in the treatment group decreased significantly(P < 0.05), LVEF of treatment group increased significantly(P < 0.05). Conclusion Intensive heart rate control in patients with chronic heart failure can significantly reduce Inflammatory factor levels and improve the cardiac function.关键词
心率/炎症因子/慢性心力衰竭/脑钠肽/心功能Key words
heart rate/inflammatory factor/chronic heart failure/brain natriuretic peptide/car-diac function引用本文复制引用
陆铭,蒋庆渊,刘春兰,刘莹莹,凌佳,阚丽红,庄晓华,蔡振荣..心率控制对慢性心力衰竭患者炎症因子及心功能的影响[J].实用医学杂志,2017,33(19):3235-3239,5.基金项目
上海市浦东医院科学技术研究项目(编号:201311) （编号:201311）
