实用医学杂志2017，Vol.33Issue(19)：3255-3260,6.DOI:10.3969/j.issn.1006-5725.2017.19.026
帕金森病合并抑郁与血清细胞因子的相关研究
The role of inflammatory cytokines in patients with depression in Parkinson's disease
摘要
Abstract
Objective To compare the serum levels of interleukin(IL)-6,IL-18 and tumor necrosis factor alpha(TNF-α)in patients with DPD,PD,depression disorder and healthy controls and to analyze the correlations of serum inflammatory factors in DPD patients. Methods Serum levels of IL-6,IL-18 and TNF-αwere measured using enzyme linked immunosorbent assay(ELISA) kits. Several scales were performedin DPD patients. Results DPD,PD and depression disorder patients had significant lower baseline levels of IL-6 and TNF-αwhen compared to healthy controls(P < 0.05). The levels of IL-6 and TNF-α in DPD patients were significantly increased after 4 weeks of anti-depression treatment(P < 0.05). No difference of cytokines levels in gender and in severity of DPD patients was detected Serum levels of these inflammatory cytokines were not significantly correlated with the UP-DRS Ⅲ,H & Y,MMSE and HAMD scores in DPD patients. Conclusions Serum inflammatory factors(IL-6, TNF-α)were altered in patients with DPD in the earlier course of disease. However ,the role of IL-18 remained unknownin the occurrence of DPD disease.关键词
帕金森病/抑郁症/帕金森病合并抑郁/IL-6/IL-18/TNF-αKey words
depression in Parkinson′s disease/Parkinson′s disease/depression disorder/IL-6/IL-18/TNF-α引用本文复制引用
欧阳樱君,吴爱武,余健敏,张惠丽,戴卉..帕金森病合并抑郁与血清细胞因子的相关研究[J].实用医学杂志,2017,33(19):3255-3260,6.基金项目
广东省科技厅项目(编号:2013B021800062) （编号:2013B021800062）
广州市医药卫生科技项目(编号:20161A011002) （编号:20161A011002）
