实用医学杂志2017，Vol.33Issue(20)：3397-3401,5.DOI:10.3969/j.issn.1006-5725.2017.20.017
线粒体DNA含量与急性冠脉综合征的关系
Relationship between mitochondrial DNA content and acute coronary syndrome
摘要
Abstract
Objective To investigate the relationship between peripheral blood mtDNA content and acute coronary syndrome. Methods A total of 244 patients who received coronary angiography(CAG)was enrolled in this study. They were divided into acute coronary syndrome(ACS)group(n=183)and control group(n=61)ac-cording to the CAG results. A quantitative real-time PCR-based method was used to measure relative content of mtDNA in peripheral blood. According to lesion blood vessel counts ,ACS patients were divided into single lesion group,double lesion group and three lesions group. Gensini score was used to quantitatively evaluate the severity of coronary stenotic lesions. Then we analyzed the relationship of mitochondrial DNA content with the lesion counts and the Gensini score. Results The ACS group had a lower mtDNA content ,as compared to controls (P <0.001).The lesion blood vessel count and mtDNA content in the single ,double and three vascular lesions group were all significanlty lower than that of the control group(P<0.05)and that of the double,three vascular lesions group were both significantly lower than that of the single vascular lesion group(P<0.05). According to the Gensi-ni score,all patients were divided into four groups,where with mtDNA content was decreased with the increase of the Gensini score(P < 0.01). The linear regression analysis showed that Gensini score was negatively correlated with mtDNA content(r=-0.644,P<0.001). ROC curve analysis showed that the area under the curve of mtDNA content for ACS diagnosis was 0.855(P<0.001),with the sensitivity and specificity of 0.756 and 0.833,respec-tively. Conclusion MtDNA content is closely associated with ACS and the Gensini score ,the latter indicating the severity of coronary stenotic lesions. MtDNA content detection has its value in the diagnosis of ACS.关键词
mtDNA含量/急性冠脉综合征/冠脉狭窄程度Key words
mtDNA content/acute coronary syndrome/severity of coronary stenotic lesions引用本文复制引用
董文超,丁振江,王瑞鹃,王鹏飞,侯维娜,严亚琪,李硕..线粒体DNA含量与急性冠脉综合征的关系[J].实用医学杂志,2017,33(20):3397-3401,5.基金项目
国家自然科学基金(编号:81000068) （编号:81000068）
河北省引进留学人员资助项目(编号:C2015005001) （编号:C2015005001）
